Skip to main content
SearchLoginLogin or Signup

Review of "Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway"

Reviewer: Alina Chan (Broad Institute) | πŸ“—πŸ“—πŸ“—πŸ“—β—»οΈ

Published onMar 24, 2022
Review of "Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway"
key-enterThis Pub is a Review of
Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway
Description

AbstractSARS-CoV-2 has a broad mammalian species tropism infecting humans, cats, dogs and farmed mink. Since the start of the 2019 pandemic several reverse zoonotic outbreaks of SARS-CoV-2 have occurred in mink, one of which reinfected humans and caused a cluster of infections in Denmark. Here we investigate the molecular basis of mink and ferret adaptation and demonstrate the spike mutations Y453F, F486L, and N501T all specifically adapt SARS-CoV-2 to use mustelid ACE2. Furthermore, we risk assess these mutations and conclude mink-adapted viruses are unlikely to pose an increased threat to humans, as Y453F attenuates the virus replication in human cells and all 3 mink-adaptations have minimal antigenic impact. Finally, we show that certain SARS-CoV-2 variants emerging from circulation in humans may naturally have a greater propensity to infect mustelid hosts and therefore these species should continue to be surveyed for reverse zoonotic infections.

To read the original manuscript, click the link above.

Since our solicitation of reviews, this preprint has been published in Cell journal and the link to the published manuscript can be found here.

Reviewer 1 (Alina Chan) | πŸ“—πŸ“—πŸ“—πŸ“—β—»οΈ

RR:C19 Strength of Evidence Scale Key

πŸ“• ◻️◻️◻️◻️ = Misleading

πŸ“™πŸ“™ ◻️◻️◻️ = Not Informative

πŸ“’πŸ“’πŸ“’ ◻️◻️ = Potentially Informative

πŸ“—πŸ“—πŸ“—πŸ“—β—»οΈ = Reliable

πŸ“˜πŸ“˜πŸ“˜πŸ“˜πŸ“˜ = Strong

To read the review, click the link below.Β 

Comments
1
Vape Factory:

https://lifeinsys.com/user/vapecig

https://www.funddreamer.com/users/vapecig

https://parler.com/vapecig

https://defol.io/ecigator-new

https://www.fertstertdialog.com/users/matthew-ma

https://lykeios.it/forums/users/vapecig/

https://rusua.ru/community/profile/vapecig/

https://fbbcrew.com/forum/profile/vapecig/

http://artisticpisceshk.com/forum/profile/vapecig/

https://community.minimaxxtuner.com/community/profile/vapecig/

https://www.pnc-contact.com/forums/users/vapecig

https://www.maliweb.net/author/vapecig

https://villatheme.com/supports/users/vapecig/

https://agentdrive.com/author/vapecig/

https://offgridworld.com/author/vapecig/

https://aspe.net/forums/users/14ce063a-fd43-ecf5-220f6547c0a02232/

https://studiopress.community/users/vapecig/

https://jazztokyo.org/forums/users/vapecig/

https://drandrewsargent.com/forums/users/vapecig/

https://rpgplayground.com/members/vapecig/profile/

https://dotnettutorials.net/forums/users/vapecig/

https://oilpatchsurplus.com/author/vapecig/

https://www.guiafacillagos.com.br/author/vapecig/

https://www.portalmundos.com/profile/vapecig/

https://militaryscalemodelling.com/members/vapecig/profile/

https://sciter.com/forums/users/vapecig/

https://www.watchfaces.be/forums/users/vapecig/

https://rabbitroom.com/members/vapecig/profile/

https://sub4sub.net/forums/users/vapecig/

https://www.joinarticles.com/author/vapecig/

https://actuma.nl/author/vapecig/

https://blavida.com/members/vapecig/

https://www.rosasensat.org/forums/users/ecigatornewgmail-com/

https://www.canadavideocompanies.ca/forums/users/vapecig/

https://www.inkston.com/community/forums/users/vapecig

https://planningengineer.net/forums/users/vapecig/

https://itbusiness.com.ua/author/vapecig

https://foro.zendalibros.com/forums/users/vapecig/

https://forum.prusa3d.com/forum/profile/512978/

http://jobboard.piasd.org/author/vapecig/

https://www.pxworks.io/author/vapecig/

http://enzoworldwide.com/forum/profile/vapecig/

https://mentorsano.com/community/profile/vapecig/

https://prysmatique.com/community/profile/vapecig/

https://www.coachlife.com.mx/foro/profile/vapecig/

https://www.hogwartsishere.com/1467175/

http://anyflip.com/homepage/uyjnk

https://es.radiocut.fm/user/ecignew/

https://yolotheme.com/forums/users/vapecig/

https://learn.acloud.guru/profile/ecigator-proton-me

https://noi.italiani.it/members/vapecig/info/

https://imageevent.com/vapecig

http://phpbt.online.fr/profile.php?mode=view&uid=5756

http://sharedsuccessglobal.com/marketplace/ecignew

http://sharedsuccessglobal.com/marketplace/forums/thread/41/

https://community.chocolatey.org/profiles/vapecig

https://www.free-education-scandiano.it/author/vapecig/

https://www.chordie.com/forum/profile.php?id=1520467

http://hyunsdojo.com/user.php?u=vapecig&page=about

https://www.inkitt.com/vapecig

https://www.strata.com/forums/users/vapecig

https://www.tetongravity.com/community/profile/m555e7/

https://caribbeanfinder.com/profile/vapecig

https://photocufi.it/community/profile/vapecig/

https://vrc.org.au/forums/users/vapecig

https://www.stressrejectersnation.com/community/profile/vapecig/

https://forums.softraid.com/profile/vapecig/

https://www.nationalbraille.org/forums/users/vapecig/

https://house.karuizawa.co.jp/forums/users/vapecig/

https://ciuci.us/alumni-network-forum/profile/vapecig/

https://qhvsg.org.au/forums/users/vapelife/

https://pacoherrero.es/forums/users/ecigatornew/

https://www.sa4x4.co.za/forums/users/vapecig/

https://hermit.edu.vn/profile/vapecig/

https://www.lullabytrust.org.uk/forums/users/vapecig/

https://www.espace-recettes.fr/profile/vapecig/630953

http://www.sign-ific-ance.co.uk/index.php/jihararabic/comment/view/1673/0/102073

http://www.sign-ific-ance.co.uk/index.php/jihararabic/user/viewPublicProfile/1180440

http://journals.hnpu.edu.ua/index.php/literature/user/viewPublicProfile/1689

https://ubld.it/forums/users/vapecig/

https://bioeast.eu/forums/users/ecigator-new/

https://engs.sabu.edu.ly/profile/vapenew/

https://asean-aipr.org/forums/users/moonswamp/

https://kriesi.at/support/profile/moonswamp/

https://simple-membership-plugin.com/forums/users/vapecig/

https://www.rgptoronto.ca/forums/users/vape-factory/

https://interreg-euro-med.eu/forums/users/vapecig/

https://wikifaunia.com/forums/users/vapenew/

https://exceltips.eu/author/vapecig/

https://knifeland.eu/author/vapenew/

https://examqa.com/forum/profile/vapecig/

https://www.freefullpdf.com/members/vapecig/

https://robotex.ee/foorum/profile/vapecig/

https://affinity-space.com/community/profile/vapenew/

https://www.wec.org/forums/users/vapecig/

https://www.traditionalanimation.com/author/vapecig/

https://glamorouslengths.com/author/vapecig/

https://climbkalymnos.com/forums/users/vapecig/

https://surgezirc.co.za/author/vapecig

https://skills.stu.edu.iq/profile/vapecig

https://www.shippingexplorer.net/de/user/vapecig/84501

https://www.neodelight.com/author/vapecig/

https://www.brighteaglets.edu.pk/profile/vapecig/

https://www.koolmoves.com/blog/forums/users/vapecig/

https://api.sg/forums/users/vapecig/

https://lancephan.com/author/vapecig/

https://www.edna.cz/uzivatele/vapecig/

https://circaoldhouses.com/agent/vapecig

https://valuesparenting.com/forums/users/vapecig/

https://www.apdaparkinson.org/profile/vapecig/

https://critterfam.com/forums/users/vapecig/

https://knowledge4food.net/members/vapecig/

https://auburn.nsta.edu.au/profile/vapecig/

http://www.hoektronics.com/author/vapecig/

https://wperp.com/users/vapecig/

https://r3media.ro/author/vapecig/

http://amuf.fr/forums/users/vapecig/

http://forums.powerhoster.com/forums/users/vapecig/

https://painsupport.co.uk/forums/users/vapecig/

http://difh.ordemfarmaceuticos.pt/forums/users/ecigatornewgmail-com/

https://www.shopolog.ru/users/vapecig/

https://learning.edanz.com/forums/users/ecigatornewgmail-com/

https://www.asnr.org/forums/users/ecigatornewgmail-com/

https://sarawakvoice.com/author/vapecig/

https://www.hochgepokert.com/author/vapecig/

https://www.ortodoxia.md/author/vapecig/

https://www.wayaround.com/community/users/ecigatornewgmail-com/

https://www.thelocationguide.com/forums/users/ecigatornewgmail-com/

https://www.cherryframework.com/v3/forums/users/vapecig/

https://examguide.co.in/discussion-board/profile/vapecig/

https://eligon.ro/community/profile/vapecig/

https://www.propelio.com/academy/community/profile/vapecig/

https://bitcoinblack.net/community/vapecig/info/

https://cadillacsociety.com/users/vapecig/

https://miriam.net.pl/community/profile/vapecig/

https://jurnal.uns.ac.id/joive/user/viewPublicProfile/3682449

https://alexathemes.net/forums/users/ecigator/

http://winnipeg.pinklink.ca/author/vapecig/

https://ourblogginglife.com/community/profile/vapecig/

https://www.giswater.org/foro/profile/vapecig/

https://www.asetek.com/simsports/community/profile/vapecig/

https://participa.fard.mil.do/foro/perfil/3149/

https://islamiccentral.org/community/profile/vapecig/

https://www.fundable.com/vape-factory

https://writeupcafe.com/profile/vapecig/

https://rpgamer.com/user/vapecig/

https://hanson.net/users/vapecig

https://cuerious.com/@ecigator

https://www.bloggalot.com/profile/vapecig

https://www.1001pallets.com/author/vapecig/

https://www.fdb.cz//clen/193489-vapecig.html

https://www.thetodayposts.com/author/vapecig/

https://www.spontis.de/mitglieder/liste/vapecig/

https://www.fmconsulting.net/gymsforsale/author/vapecig/

https://www.sellmytires.com/author/vapecig/

https://nybrowning.org/message-board/profile/vapecig/

https://www.toysoldiersunite.com/members/vapecig/profile/

https://search.mimioconnect.com/users/vapecig

https://decidim.barcelonaenergia.cat/profiles/vapecig/activity

https://club.decidim.opensourcepolitics.eu/profiles/vapecig/activity

https://www.elseptimoarte.net/foro/index.php?action=profile;area=summary;u=21218

http://www.blackhatway.com/index.php?action=profile;area=summary;u=1539407

https://www.elitetrack.com/forums/users/vapecig/

https://tinkerine.com/user/vapecig

https://www.retecool.com/author/vapecig/

https://planetes360.fr/author/vapenew/

http://www.ihoneida.com/author/vapecig/

https://nezuko.us/author/vapecig/

https://www.energyplan.eu/forums/users/vapecig/

https://pentestmag.com/forums/users/vapecig/

https://beninwebtv.com/author/vapecig/

https://weltexpress.info/author/vapecig/

https://bentleyforum.nl/forums/users/vapecig

https://sensationaltheme.com/forums/users/vapecignew/

https://www.myhoroscope.gr/author/vapecig/

http://dobrepole.esy.es/author/vapecig/

http://web.symbol.rs/forum/member.php?action=profile&uid=162834

https://bunkersnack.se/forums/users/vapenew/

https://www.unwantedwitness.org/cyberpolicy/forums/users/vapecig/

https://phuket.mol.go.th/forums/users/vapecig

https://www.eurofleets.eu/forums/users/vapecig/

https://www.aiatlanta.org/forums/users/vapecig/

https://www.barcawelt.de/author/vapecig/

https://itech.co.ua/author/vapecig/

https://www.marqueze.net/miembros/vapecig/profile/classic/

https://vadea.viaafrika.com/forums/users/vapecig/

https://www.openwebtech.fr/author/vapecig/

https://euvoudemochila.com.br/author/vapecig/

https://www.thedailynews.ng/author/vapenew/

https://productdesignhub.com/directory/author/vapecig/

https://towyardcars.com/author/vapecig/

https://www.puskapik.com/author/vapecig/

https://zenica.co.ba/author/vapecig/

http://praca.poland.us/author/vapecig/

http://praca.poland.us/author/vapecig/

https://www.itinerantangler.com/blog/board/forums/users/vapecig

https://new.miamisprings.com/author/vapecig/

https://www.autocaravanas.es/foro/usuarios/vapecig/

https://pinoy1tvs.su/author/vapecig/

https://medibulletin.com/author/vapecig/

https://outof.cards/members/vapecig/

https://knightnews.com/author/vapenew/

https://galsenfoot.sn/author/vapecig/

https://petsarepeopletoo.biz/forums/users/vapecig/

https://new.miamisprings.com/author/vapenew/

https://thenewsavvy.com/members/vapecig/

https://ksonline.ru/author/vapecig/

https://bauernzeitung.at/author/vapecig/

https://solorider.com/forums/users/vapecig

http://www.trainingpages.com/author/vapecig/

https://myrtlebeachsc.com/author/vapenew/

https://trabajo.merca20.com/author/vapecig/

https://directory.womengrow.com/author/vapecig/

https://community.cleanbrowsing.org/users/vapecig/

https://styloplanet.com/author/vapecig/

https://www.sxm-talks.com/author/vapecig/

https://voiceofmotown.com/author/vapecig/

https://www.nientepopcorn.it/forums/users/vapecig/

http://divisionmidway.org/jobs/author/vapecig/

https://mthfrsupport.com/forums/users/ecigatornew/

https://www.gunners.cz/author/vapecig/

https://www.easylanguageexchange.com/users/vapecig/

https://cyber.pressball.by/author/vapecig/

https://bagogames.com/author/vapecig/

https://orangelifemagazine.com/author/vapecig/

https://hamroprice.com/author/vapecig/

https://www.mychesco.com/members/vapecig/profile/

http://aquapioneers.io/community-forum/users/vapecig

https://bitcoinpeople.online/author/vapecig

https://techmaniacs.gr/author/vapecig/

https://www.mindspec.org/author/vapenew/

https://www.zerostriker.com/author/vapecig/

https://www.le-republicain.fr/author/vapecig

https://stpaulkatni.edu.in/forums/users/vapecig/

https://matchstickpro.com/members-2/vapenew/info/

https://www.runnerspace.com/profile.php?member_id=573030

https://www.rafabasa.com/author/vapecig/

https://rightsidenews.com/author/vapecig/

https://space.mya.co.uk/mya-forums/users/vapenew/

https://installers.hdbaset.org/pt-pt/forums/users/ecigatornewgmail-com/

https://www.genglobal.org/user/130352

https://dearwendy.com/users/vapecig/

https://www.alnas.fr/author/vapenew/

http://test.vnushator.ru/members/vapecig/

https://localnews8.com/author/vapenew/

http://test.vnushator.ru/members/vapecig/activity/1160243/

https://www.dgsalt.org/members/vapenew/

https://www.dgsalt.org/members/vapenew/activity/544785/

https://www.opimec.org/personas/vapecig/

https://egpu.io/forums/profile/vapecig/