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Review of "Universal Protection against SARS-CoV-2 Viruses by Multivalent mRNA Vaccine in Mice"

Reviewers: M Gaglia (University of Wisconsin-Madison) | 📒📒📒 ◻️◻️

Published onJul 01, 2024
Review of "Universal Protection against SARS-CoV-2 Viruses by Multivalent mRNA Vaccine in Mice"

To read the original manuscript, click the link above.

Summary of Reviews: The reviewer found the study potentially informative, examining the antibody responses to a multi-valent mRNA vaccine for SARS-CoV-2. While the methods were deemed appropriate and the results interesting, the reviewer highlighted several limitations. These included unclear generalizability, questions about whether the response was truly polyvalent, and a lack of detail in various aspects of the study design and methods. The reviewer noted that the main finding - that a multivalent vaccine may elicit a broad response affecting strains not included in the vaccine - was interesting, but suggested that further research with different virus combinations and more divergent strains would be necessary to fully support the authors' conclusions.

Reviewer 1 (Marta G…) | 📒📒📒 ◻️◻️

RR:C19 Strength of Evidence Scale Key

📕 ◻️◻️◻️◻️ = Misleading

📙📙 ◻️◻️◻️ = Not Informative

📒📒📒 ◻️◻️ = Potentially Informative

📗📗📗📗◻️ = Reliable

📘📘📘📘📘 = Strong

To read the reviews, click the links below. 

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