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Reviews of "A live attenuated vaccine offers superior mucosal and systemic immunity to SARS-CoV-2"

Reviewers: Qiuhong Wang, Mingde Liu (Ohio State University) | 📘📘📘📘📘 • Rachel Palinski (Kansas State University) | 📗📗📗📗◻️

Published onJun 24, 2022
Reviews of "A live attenuated vaccine offers superior mucosal and systemic immunity to SARS-CoV-2"
key-enterThis Pub is a Review of
A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants

AbstractVaccines are a cornerstone in COVID-19 pandemic management. Here, we compare immune responses to and preclinical efficacy of the mRNA vaccine BNT162b2, an adenovirus-vectored spike vaccine, and the live-attenuated-virus vaccine candidate sCPD9 after single and double vaccination in Syrian hamsters. All regimens containing sCPD9 showed superior efficacy. The robust immunity elicited by sCPD9 was evident in a wide range of immune parameters after challenge with heterologous SARS-CoV-2 including rapid viral clearance, reduced tissue damage, fast differentiation of pre-plasmablasts, strong systemic and mucosal humoral responses, and rapid recall of memory T cells from lung tissue. Our results demonstrate that use of live-attenuated vaccines may offer advantages over available COVID-19 vaccines, specifically when applied as booster, and may provide a solution for containment of the COVID-19 pandemic.

To read the original manuscript, click the link above.

Summary of Reviews: This preprint reports improved immune responses to and efficacy of a live attenuated SARS-CoV-2 vaccine, compared to Pfizer mRNA vaccine, and an adenovirus-vectored spike protein vaccine (Ad2) in hamsters. Reviewers find the study significant, with the data presented as reliable.

Reviewer 1 (Qiuhong Wang,Mingde Liu) | 📘📘📘📘📘

Reviewer 2 (Rachel Palinski) | 📗📗📗📗◻️

RR:C19 Strength of Evidence Scale Key

📕 ◻️◻️◻️◻️ = Misleading

📙📙 ◻️◻️◻️ = Not Informative

📒📒📒 ◻️◻️ = Potentially Informative

📗📗📗📗◻️ = Reliable

📘📘📘📘📘 = Strong

To read the reviews, click the links below.

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