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Reviews of "Adverse effects and antibody titers in response to the BNT162b2 mRNA COVID-19 vaccine in a prospective study of healthcare workers"

Reviewers: Yang Xiaoming (China National Biotech Group) | 📒📒📒◻️◻️ • Alberto Modenese (University of Modena and Reggio Emilia) | 📗📗📗📗◻️

Published onAug 04, 2021
Reviews of "Adverse effects and antibody titers in response to the BNT162b2 mRNA COVID-19 vaccine in a prospective study of healthcare workers"
key-enterThis Pub is a Review of
Adverse effects and antibody titers in response to the BNT162b2 mRNA COVID-19 vaccine in a prospective study of healthcare workers

AbstractBackgroundmRNA COVID-19 vaccines are playing a key role in controlling the COVID-19 pandemic. The relationship between post-vaccination symptoms and strength of antibody responses is unclear.ObjectiveTo determine whether adverse effects caused by vaccination with the Pfizer/BioNTech BNT162b2 vaccine are associated with the magnitude of vaccine-induced antibody levels.DesignSingle center, prospective, observational cohort study.SettingParticipants worked at Walter Reed National Military Medical Center and were seen monthly at the Naval Medical Research Center Clinical Trials Center.ParticipantsGenerally healthy adults that were not severely immunocompromised, had no history of COVID-19, and were seronegative for SARS-CoV-2 spike protein prior to vaccination.MeasuresSeverity of vaccine-associated symptoms was obtained through participant completed questionnaires. Testing for IgG antibodies against SARS-CoV-2 spike protein and receptor binding domain was conducted using microsphere-based multiplex immunoassays.Results206 participants were evaluated (69.4% female, median age 41.5 years old). We found no correlation between vaccine-associated symptom severity scores and vaccine-induced antibody titers one month after vaccination. We also observed that 1) post-vaccination symptoms were inversely correlated with age and weight and more common in women, 2) systemic symptoms were more frequent after the second vaccination, 3) high symptom scores after first vaccination were predictive of high symptom scores after second vaccination, and 4) older age was associated with lower titers.LimitationsStudy only observes antibody responses and consists of healthy participants.ConclusionsLack of post-vaccination symptoms following receipt of the BNT162b2 vaccine does not equate to lack of vaccine-induced antibodies one month after vaccination. This study also suggests that it may be possible to design future mRNA vaccines that confer robust antibody responses with lower frequencies of vaccine-associated symptoms.FundingThis study was executed by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed by the Uniformed Services University of the Health Sciences (USUHS) through a cooperative agreement by the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF). This project has been funded by the Defense Health Program, U.S. DoD, under award HU00012120067. Project funding for JHP was in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. The funding bodies have had no role in the study design or the decision to submit the manuscript for publication.

To read the original manuscript, click the link above.

Summary of Reviews: This preprint investigates antibody titer and whether titer correlates with a variety of parameters, including age, weight, sex, and post-vaccine symptom severity. Reviewers deem date reliable with only minor revision to data analysis.

Reviewer 1 (Yangxiao Ming) | 📒📒📒 ◻️◻️

Reviewer 2 (Alberto Modenese) | 📗📗📗📗◻️

RR:C19 Strength of Evidence Scale Key

📕 ◻️◻️◻️◻️ = Misleading

📙📙 ◻️◻️◻️ = Not Informative

📒📒📒 ◻️◻️ = Potentially Informative

📗📗📗📗◻️ = Reliable

📘📘📘📘📘 = Strong

To read the reviews, click the links below. 

Yash Malhotra:

Amazing research about Covid 19. if you are feeling laziness and nothing to do then you can watch desi entertainment shows at, or at and updates at

Lisa Rose:

Hey there! 👋 It's great to see research like this exploring the effects of the COVID-19 vaccine. The fact that lack of post-vaccination symptoms doesn't necessarily mean a lack of vaccine-induced antibodies is reassuring. It's essential to understand how our bodies respond to these vaccines.

Kudos to the researchers for shedding light on this aspect. Keep up the fantastic work, and let's continue to fight this pandemic together! 💪 #ScienceMatters 🌍🔬

samy ali:

very good post. لعبة بادل

davis john:

There were no reported adverse effects or antibody titers in any of the healthcare workers who were vaccinated with nyt mini crossword the BNT162b2 mRNA COVID-19 vaccine.