Description
Background: Enteric fever caused by Salmonella Typhi and Paratyphi A is an important public health problem, especially in low- and middle-income countries with
Reviewers: M Carey (London School of Hygiene and Tropical Medicine) | ππππβ»οΈ β’ K Neuzil (University of Maryland) | ππππβ»οΈ β’ M Laurens (University of Maryland) | πππππ
To read the original manuscript, click the link above.
Summary of Reviews: This preprint details the result of a phase 1 vaccine trial of a bivalent Paratyphoid A-Typhoid Conjugate Vaccine in healthy adults. The authors found that this vaccine was safe and immunogenic for both typhoid and paratyphoid antigen. The general consensus among reviewers was that this study was reliable, highlights important evidence for the immunogenicityΒ for this novel vaccine, and has important implications for future clinical development.
Reviewer 1 (Megan Cβ¦) | ππππβ»οΈ
Reviewer 2 (Kathleen Nβ¦) | ππππβ»οΈ
Reviewer 3 (Matthew Lβ¦) | πππππ
RR:C19 Strength of Evidence Scale Key π β»οΈβ»οΈβ»οΈβ»οΈ = Misleading ππ β»οΈβ»οΈβ»οΈ = Not Informative πππ β»οΈβ»οΈ = Potentially Informative ππππβ»οΈ = Reliable πππππ = Strong |
To read the reviews, click the links below.Β