Description
Background: Enteric fever caused by Salmonella Typhi and Paratyphi A is an important public health problem, especially in low- and middle-income countries with
Reviewers: M Carey (London School of Hygiene and Tropical Medicine) | 📗📗📗📗◻️ • K Neuzil (University of Maryland) | 📗📗📗📗◻️ • M Laurens (University of Maryland) | 📘📘📘📘📘
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Summary of Reviews: This preprint details the result of a phase 1 vaccine trial of a bivalent Paratyphoid A-Typhoid Conjugate Vaccine in healthy adults. The authors found that this vaccine was safe and immunogenic for both typhoid and paratyphoid antigen. The general consensus among reviewers was that this study was reliable, highlights important evidence for the immunogenicity for this novel vaccine, and has important implications for future clinical development.
Reviewer 1 (Megan C…) | 📗📗📗📗◻️
Reviewer 2 (Kathleen N…) | 📗📗📗📗◻️
Reviewer 3 (Matthew L…) | 📘📘📘📘📘
RR:C19 Strength of Evidence Scale Key 📕 ◻️◻️◻️◻️ = Misleading 📙📙 ◻️◻️◻️ = Not Informative 📒📒📒 ◻️◻️ = Potentially Informative 📗📗📗📗◻️ = Reliable 📘📘📘📘📘 = Strong |
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