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Review of "SARS-CoV-2 infection results in lasting and systemic perturbations post recovery"

Reviewer: Rajkumar Kalra (Okinawa Institute of Science and Technology Graduate University) | 📒📒📒 ◻️◻️

Published onMay 26, 2022
Review of "SARS-CoV-2 infection results in lasting and systemic perturbations post recovery"
key-enterThis Pub is a Review of
SARS-CoV-2 infection results in lasting and systemic perturbations post recovery

SUMMARYSARS-CoV-2 has been found capable of inducing prolonged pathologies collectively referred to as Long-COVID. To better understand this biology, we compared the short- and long-term systemic responses in the golden hamster following either SARS-CoV-2 or influenza A virus (IAV) infection. While SARS-CoV-2 exceeded IAV in its capacity to cause injury to the lung and kidney, the most significant changes were observed in the olfactory bulb (OB) and olfactory epithelium (OE) where inflammation was visible beyond one month post SARS-CoV-2 infection. Despite a lack of detectable virus, OB/OE demonstrated microglial and T cell activation, proinflammatory cytokine production, and interferon responses that correlated with behavioral changes. These findings could be corroborated through sequencing of individuals who recovered from COVID-19, as sustained inflammation in OB/OE tissue remained evident months beyond disease resolution. These data highlight a molecular mechanism for persistent COVID-19 symptomology and characterize a small animal model to develop future therapeutics.

To read the original manuscript, click the link above.

Reviewer 1 (Rajkumar Kalra) | 📒📒📒 ◻️◻️

RR:C19 Strength of Evidence Scale Key

📕 ◻️◻️◻️◻️ = Misleading

📙📙 ◻️◻️◻️ = Not Informative

📒📒📒 ◻️◻️ = Potentially Informative

📗📗📗📗◻️ = Reliable

📘📘📘📘📘 = Strong

To read the review, click the link below.

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PASC, custom wordle also known as extended COVID and defined as continuous, relapsing, or novel symptoms or illnesses present 30 days or more after infection, is a major clinical and public health concern.

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SARS-CoV-2 is the virus that causes COVID-19, a disease that has had a significant impact on the world. There are many studies and reviews related to SARS-CoV-2 and COVID-19, including research on the accuracy of COVID-19 tests the long-term effects of COVID-19 infections, and the global impact of the pandemic. Additionally, there have been studies on the risk of reinfection with SARS-CoV-2. Overall, there is a significant amount of research being conducted on SARS-CoV-2 and COVID-19, and new findings are being published regularly.

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