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Review for "Generation and transmission of inter-lineage recombinants in the SARS-CoV-2 pandemic"

Graziano Pesole & Matteo Chiara (University of Bari) 📗📗📗📗◻️

Published onNov 18, 2021
Review for "Generation and transmission of inter-lineage recombinants in the SARS-CoV-2 pandemic"
key-enterThis Pub is a Review of
Generation and transmission of inter-lineage recombinants in the SARS-CoV-2 pandemic

We present evidence for multiple independent origins of recombinant SARS-CoV-2 viruses sampled from late 2020 and early 2021 in the United Kingdom. Their genomes carry single nucleotide polymorphisms and deletions that are characteristic of the B.1.1.7 variant of concern, but lack the full complement of lineage-defining mutations. Instead, the remainder of their genomes share contiguous genetic variation with non-B.1.1.7 viruses circulating in the same geographic area at the same time as the recombinants. In four instances there was evidence for onward transmission of a recombinant-origin virus, including one transmission cluster of 45 sequenced cases over the course of two months. The inferred genomic locations of recombination breakpoints suggest that every community-transmitted recombinant virus inherited its spike region from a B.1.1.7 parental virus, consistent with a transmission advantage for B.1.1.7's set of mutations.

Since our solicitation of reviews, this preprint has been published in Cell journal and the link to the published manuscript can be found here.

Reviewers: Graziano Pesole, Matteo Chiara

To read the original manuscript, click the link above.

Summary of Reviews: This preprint analyzes all complete UK SARS-CoV-2 genomes that were from the B.1.1.7 lineage to identify putative SARS-CoV-2 recombinant viruses. The reviewer deems the data as potentially informative but empathizes limitations in the methodological protocol.

Reviewer 1 (Graziano Pesole and Matteo Chiara) | 📗📗📗📗◻️

RR:C19 Strength of Evidence Scale Key

📕 ◻️◻️◻️◻️ = Misleading

📙📙 ◻️◻️◻️ = Not Informative

📒📒📒 ◻️◻️ = Potentially Informative

📗📗📗📗◻️ = Reliable

📘📘📘📘📘 = Strong

To read the reviews, click the links below. 

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