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Reviews of "Incident autoimmune diseases in association with a SARS-CoV-2 infection: A matched cohort study"

Reviewers: R Wood (Public Health Scotland) | 📗📗📗📗◻️ • A. Tello-Mercado and A Ponce-de-Leon ( Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán) | 📗📗📗📗◻️

Published onMar 20, 2023
Reviews of "Incident autoimmune diseases in association with a SARS-CoV-2 infection: A matched cohort study"
key-enterThis Pub is a Review of
Incident autoimmune diseases in association with a SARS-CoV-2 infection: A matched cohort study

AbstractObjectivesTo investigate whether the risk of developing an incident autoimmune disease is increased in patients with previous COVID-19 disease compared to people without COVID-19.MethodA cohort was selected from German routine health care data covering 38.9 million individuals. Based on documented diagnoses, we identified individuals with polymerase chain reaction (PCR)-confirmed COVID-19 through December 31, 2020. Patients were matched 1:3 to control patients without COVID-19. Both groups were followed up until June 30, 2021. We used the four quarters preceding the index date until the end of follow-up to analyze the onset of autoimmune diseases during the post-acute period. Incidence rates (IR) per 1000 person-years were calculated for each outcome and patient group. Poisson models were deployed to estimate the incidence rate ratios (IRRs) of developing an autoimmune disease conditional on a preceding diagnosis of COVID-19.ResultsIn total, 641,704 patients with COVID-19 were included. Comparing the incidence rates in the COVID-19 (IR=15.05, 95% CI: 14.69-15.42) and matched control groups (IR=10.55, 95% CI: 10.25-10.86), we found a 42.63% higher likelihood of acquiring autoimmunity for patients who had suffered from COVID-19. This estimate was similar for common autoimmune diseases, such as Hashimoto thyroiditis, rheumatoid arthritis, or Sjögren syndrome. The highest IRR was observed for autoimmune disease of the vasculitis group. Patients with a more severe course of COVID-19 were at a greater risk for incident autoimmune diseases.ConclusionsSARS-CoV-2 infection is associated with an increased risk of developing new-onset autoimmune diseases after the acute phase of infection.

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Summary of Reviews: This study examined the association between SARS-CoV-2 infection and autoimmune disease. Reviewers found this study to be reliable. It presents robust evidence demonstrating an association between SARS-CoV-2 infection and increased risk of incident autoimmune disease 3-15 months following infection, and its limitations are well covered in the discussion.

Reviewer 1 (Rachel Wood…) | 📗📗📗📗◻️

Reviewer 2 (Andrea C. T… and Alfredo P…) | 📗📗📗📗◻️

RR:C19 Strength of Evidence Scale Key

📕 ◻️◻️◻️◻️ = Misleading

📙📙 ◻️◻️◻️ = Not Informative

📒📒📒 ◻️◻️ = Potentially Informative

📗📗📗📗◻️ = Reliable

📘📘📘📘📘 = Strong

To read the reviews, click the links below. 

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able victor:

The association between SARS-CoV-2 infection and increased risk of autoimmune disease occurring 3-15 months after infection and its limitations were well covered in the discussion. This issue is quite serious and needs to be discussed and considered carefully. If necessary, the Drift Boss method can be used.

Warren Spence:

Amazing soccer random! It's brilliantly informative and original; keep us posted as frequently.