Skip to main content
SearchLoginLogin or Signup

Review 4: "Serum Sphingosine-1-Phosphate as Novel Prognostic and Predictive Biomarker for COVID-19 Severity and Morbidity and Its Implications in Clinical Management"

This potentially informative article with some methodological flaws suggests that serum Sphingosine-1-Phosphate (S1P) is associated with COVID-19 severity. Further research is needed to understand if serum S1P could be provided therapeutically to reduce COVID-19 severity.

Published onOct 19, 2020
Review 4: "Serum Sphingosine-1-Phosphate as Novel Prognostic and Predictive Biomarker for COVID-19 Severity and Morbidity and Its Implications in Clinical Management"

RR:C19 Evidence Scale rating by reviewer:

  • Potentially informative. The main claims made are not strongly justified by the methods and data, but may yield some insight. The results and conclusions of the study may resemble those from the hypothetical ideal study, but there is substantial room for doubt. Decision-makers should consider this evidence only with a thorough understanding of its weaknesses, alongside other evidence and theory. Decision-makers should not consider this actionable, unless the weaknesses are clearly understood and there is other theory and evidence to further support it.

***************************************

Review:

The manuscript by Marfia et al. addresses the role of S1P as a potential biomarker for severity of Covid-19-infection in patients either being admitted at the ICU or remaining clinically stable. Despite the well-written manuscript and the sound investigation regarding the role of S1P as a biomarker of Covid-19-infection I have some major concerns regarding methodology of S1P-assessment, interpretation and discussion of the data.

1. S1P was assessed by an ELISA which is not the best established methodology of exact measurement of S1P-levels. In most studies so far the mass-spectrometric assessment of S1P-levels is propagated. Yet, the assessment of S1P by an ELISA may constitute an innovative method for the higher practicability of the assessment of S1P in clinical practice. In my opinion methodology of S1P-assessment should be discussed by the authors and the limitations of the ELISA should be stated clearly.

2. Since S1P associates with RBC- and PLT-levels as correctly stated by the authors it seems logical that throughout an acute severe infection, as this is the case for Covid-19, a transient infection-associated anemia develops and this associates with low RBC- and also with low S1P-levels. Interestingly, S1P is an independent predictor of the probability of ICU-admission as shown in the multivariate analysis in Table 6. However, the sample size of 22 patients with admission to the ICU-department limits the significance of the conclusions drawn. Furthermore, no data are available regarding therapeutic medications and supportive therapy applied to the patient sample during serum asservation. S1P-levels could be severely confounded by different treatment of the patient sample.

3. S1P reduction probably resembles an epiphenomenon of the severe inflammation seen in these patients. The authors discuss a mechanistic approach involving the pathophysiology of S1P as an etiologic factor affecting the clinical course of Covid-19 infection. From my point of view, it seems quite preliminary to draw such conclusions from the given data in the respective study.

In summary, despite my major concerns regarding the methodology of the study and the patient sample I rate the respective manuscript as potentially informative since it is so far the first study demonstrating the significant decrease of S1P levels in patients with severe Covid-19 infection. Yet, the current data are certainly not sufficient in order to enforce the statement that S1P could be a predictive biomarker for COVID-19 severity and prognosis and further studies are needed in the same direction.

Connections
1 of 3
Comments
3
AIShred GEP ECOTECH:

https://ar.aishred.com/release/110.html

https://ar.aishred.com/product/hammer-shredder.html

https://ar.aishred.com/release/108.html

https://ar.aishred.com/release/107.html

https://ar.aishred.com/release/106.html

https://ar.aishred.com/release/105.html

https://ar.aishred.com/release/104.html

https://ar.aishred.com/release/103.html

https://ar.aishred.com/release/102.html

https://ar.aishred.com/release/101.html

https://ar.aishred.com/release/100.html

https://ar.aishred.com/release/99.html

https://ar.aishred.com/release/98.html

https://ar.aishred.com/release/97.html

https://ar.aishred.com/release/96.html

https://ar.aishred.com/release/95.html

https://ar.aishred.com/release/94.html

https://ar.aishred.com/release/93.html

https://ar.aishred.com/release/92.html

https://ar.aishred.com/release/91.html

https://ar.aishred.com/release/90.html

https://ar.aishred.com/release/89.html

https://ar.aishred.com/release/88.html

https://ar.aishred.com/release/87.html

https://ar.aishred.com/release/86.html

https://ar.aishred.com/release/85.html

https://ar.aishred.com/release/84.html

https://ar.aishred.com/release/83.html

https://ar.aishred.com/release/82.html

https://ar.aishred.com/release/81.html

https://ar.aishred.com/release/80.html

https://ar.aishred.com/release/79.html

https://ar.aishred.com/release/78.html

https://ar.aishred.com/release/77.html

https://ar.aishred.com/release/76.html

https://ar.aishred.com/release/75.html

https://ar.aishred.com/release/74.html

https://ar.aishred.com/release/73.html

https://ar.aishred.com/release/72.html

https://ar.aishred.com/release/71.html

https://ar.aishred.com/release/70.html

https://ar.aishred.com/release/69.html

https://ar.aishred.com/release/68.html

https://ar.aishred.com/release/67.html

https://ar.aishred.com/release/66.html

https://ar.aishred.com/release/65.html

https://ar.aishred.com/release/64.html

https://ar.aishred.com/release/63.html

https://ar.aishred.com/release/62.html

https://ar.aishred.com/release/61.html

https://ar.aishred.com/release/60.html

https://ar.aishred.com/release/59.html

https://ar.aishred.com/release/58.html

https://ar.aishred.com/release/57.html

https://ar.aishred.com/release/56.html

https://ar.aishred.com/release/55.html

https://ar.aishred.com/release/54.html

https://ar.aishred.com/release/53.html

https://ar.aishred.com/release/52.html

https://ar.aishred.com/release/50.html

https://ar.aishred.com/release/44.html

https://ar.aishred.com/release/49.html

https://ar.aishred.com/release/46.html

https://ar.aishred.com/release/47.html

https://ar.aishred.com/release/48.html

https://ar.aishred.com/release/45.html

https://ar.aishred.com/application/construction-aggregate-processing.html

https://ar.aishred.com/application/plastic-waste-processing.html

https://ar.aishred.com/application/organic-waste-processing.html

https://ar.aishred.com/application/textile-waste-processing.html

https://ar.aishred.com/application/weee-waste-processing.html

https://ar.aishred.com/application/hazardous-waste-processing.html

https://ar.aishred.com/application/scrap-metal-processing.html

https://ar.aishred.com/application/waste-tire-processing.html

https://ar.aishred.com/application/biomass-waste-processing.html

https://ar.aishred.com/application/construction-demolition-waste-processing.html

https://ar.aishred.com/application/municipal-solid-waste-processing.html

https://ar.aishred.com/application/commercial-industrial-waste-processing.html

https://ar.aishred.com/product/roller-screen.html

https://ar.aishred.com/product/circular-vibrating-screen.html

https://ar.aishred.com/product/multiple-frequency-screen.html

https://ar.aishred.com/product/flip-flow-screen.html

Vape Factory:

https://vape.flyah.co/

https://www.craft.do/s/pGHl64BQNkG81l

https://app.pandadoc.com/document/ccbbb181d3970df0e159ae0db5bda1ce006b9684

https://typed.do/d/1TvxFfjRZqFeeYSHV6bfYC

https://coda.io/d/Meet-Coda_dHUrYkVP50q/Recommended-E-cigarette-Ranking_suRD8

https://gamma.app/public/55vw7v7cwdpzl84

https://www.taskade.com/d/YqF4axe2xCqW9cVQ?share=edit&edit=EERAydoeC9ewVw7k&as=list

https://documenter.getpostman.com/view/24696379/2s8Z6vXZEe

https://postheaven.net/vapecig/

https://postheaven.net/vapecig/about-the-vapor-from-the-e-cigarette

https://postheaven.net/vapecig/how-to-use-a-disposable-vape

https://postheaven.net/vapecig/what-is-a-disposable-vape

https://postheaven.net/vapecig/how-to-recharge-a-disposable-vape

https://postheaven.net/vapecig/what-is-the-best-disposable-vape

https://demo.writefreely.host/vapecig/

https://demo.writefreely.host/vapecig/how-to-charge-disposable-vape

https://demo.writefreely.host/vapecig/why-does-my-disposable-vape-taste-burnt

https://writee.org/vapecig/

https://writee.org/vapecig/why-does-my-disposable-vape-taste-burnt

https://writee.org/vapecig/how-to-fix-a-burnt-disposable-vape

https://vapecig.take.app/

https://pocketnotes.app/note/kXCc6hy

https://telescope.ac/vapelife/

https://telescope.ac/vapelife/zxkvsndompo0u4elvx9lyc

https://telescope.ac/vapelife/1rx7w1ejtw0qvt3ro23u51

https://penzu.com/p/8bc8364c

https://penzu.com/p/65558e82

https://www.lesswrong.com/posts/eNDdhtKGSBmukLHLk/do-e-cigarettes-help-you-quit-smoking

https://zenwriting.net/vapecig/what-happened-to-the-issue-of-vape-regulation-in-the-u-s

https://writeablog.net/vapecig/what-happened-to-the-issue-of-vape-regulation-in-the-u-s

https://writeablog.net/vapecig/what-are-the-benefits-of-disposable-vapes

https://telegra.ph/People-who-are-addicted-to-electronic-cigarettes-08-27

https://telegra.ph/The-difference-between-shisha-and-vape-11-30

https://graph.org/How-many-cigarettes-is-600-puffs-02-01

https://graph.org/Can-I-Sell-Vapes-on-Amazon-02-01

https://th.hashi.icu/vapecig/what-is-a-vape

https://th.hashi.icu/vapecig/what-is-a-vape-967m

https://posteezy.com/about-vape-device

https://notepin.co/vape/

https://vape.notepin.co/about-the-vape-device--it-is-necessary-to-have-bf4ggmd

https://mypost.io/post/about-the-vape-device

https://editor.telescope.ac/blogs/vape/h25r8e62kw2jck0d81rthk

https://editor.telescope.ac/blogs/vape/zdxgq0jirl8c99qeznywls

https://theprose.com/post/545986/lets-get-the-basics-of-vape

https://theprose.com/post/612492/is-smoke-and-vape-shop-a-good-investment

https://mydukaan.io/vapestore3+A478:A505/blog/is-disposable-vape-healthy

https://mydukaan.io/vapestore3/blog/is-vaping-cheaper-than-smoking

https://mydukaan.io/vapestore3/blog/what's-the-healthiest-vape

https://skincare.gonevis.com/some-popular-e-cigarette-recommendations/

https://skincare.gonevis.com/how-to-choose-an-e-cigarette-2/

https://vapecignew.livejournal.com/503.html

https://homment.com/l1H5OHVjZXcDaq4Ybk4k

https://homment.com/CccIJaMfDxyuavggDqCy

https://homment.com/dZUvwY6XFK8PSo0jMIx6

https://homment.com/FSBeuS017ZjfSAMYR8Xa

https://slides.com/vapecig/vape

https://ecigator.contently.com/

https://onlinehtmleditor.dev/collaboration/#doce8ef979a41

https://anotepad.com/notes/dcfn4meq

https://anotepad.com/notes/4mx5serm

https://warengo.com/stories/263598-the-difference-between-shisha-and-vape

https://www.townscript.com/e/ecigarette-explosive-smoking-132331

https://z4nd8shuds3.typeform.com/to/vbyiOkHz

https://form.jotform.com/223281115973051

https://www.beclass.com/rid=2748d1c6396e2900f09a

https://express.adobe.com/page/X42msE6GXamXo/

https://froont.com/vapecig/vape-factory

https://froont.com/vapecig

https://www.launchora.com/story/a-beginners-guide-to-using-disposable-vapes

https://www.edrawmind.com/online/map.html?sharecode=638112c84044b6a76907970

https://coggle.it/diagram/Y4SWT71Eo51jqWxN/t/disposable-vape-factory/2498349aba1ddbe2f049806185757f44da430ec1cdfe9d86a2a99829fcd81aef

https://onodo.org/visualizations/217139

https://bubbl.us/NzUxMzYyMC81MjIyMTUxLzAwMmE3YmIyYzVhNzE3OGYwOTFmM2VmZjFlNTk5YTc30

https://www.emoneyspace.com/vapfactory

https://vapefactory.straw.page

https://alchetron.com/Tron/Are-disposable-vapes-worth-it%3F-5208902-UW

https://qrcodes.pro/ROUaK5

https://jsitor.com/preview/t9QBmzn21A

https://paste.feed-the-beast.com/view/c871a9a5

http://paste.akingi.com/xXNQPm0b

https://paiza.io/projects/9LE_W0Gz_j91ZBld5tttMg

https://jsitor.com/preview/zXGhC2Drh6

https://ide.geeksforgeeks.org/online-html-editor/ebde2019-c99b-4042-aed5-46c30cf12371

https://www.pastery.net/fwfges+tauxjc/

https://justpaste.it/vapelinks

https://justpaste.it/disposvapes

https://pasteio.com/xeRbHgWXHjQb

http://pastebin.falz.net/2499501

https://paste.awesom.eu/raw/vapecig/TLWP

https://onlinegdb.com/I98N_Bx5qe

https://yamcode.com/hluokettws

https://yamcode.com/f2ihsedvzo

https://paste.toolforge.org/view/c553c2e4

https://notepad.pw/XxPEejtANAeqTKIk49SM

https://tempel.in/view/45b6a1f6

https://paste.gg/p/vapecig/a20000c50f844db3ad13198fe224b962

https://bitbin.it/0WfVktk9/

https://paste.opendev.org/show/818127/

https://pastebin.freepbx.org/view/0453a430

https://paste.cclinux.org/view/d96e5d47

http://pastebin.viradev.ir/pastebin/view/8f57f2c8

http://yatespost.com/view/70c8bf84

http://paste.vasiliy.pro/view/eb78dd64

https://paste.elyograg.org/view/1471f5fc

https://archive.ph/PuKik

https://note.vg/vape-35144

https://paste.zyrex.org/view/264bad6f

http://pastebin.loki.pitechnologies.ro/index.php/view/40824360

https://chris.teria.org/pastebin/view/2dfa0a30

http://minetest.wjake.com/stikked/view/a74ae71c

https://paste.tecnocratica.net/view/57f7e54e

https://paste.steamr.com/view/e4f62a61

http://stikked.luisaranguren.com/view/7010ba28

https://paste.artixlinux.org/view/a55b3ecd

https://paste.gajim.org/view/9045449c

https://paste.tunestiga.com/view/752f7666

http://paste.purplehat.org/view/72d8bc68

https://paste.unixkoans.com/view/bb4ffd74

http://stri1.rf.gd/view/91c5ca2d

https://jsfiddle.net/vapecig/ag2er6z7/

https://ideone.com/nP3WgL

https://controlc.com/0f24f515

https://pastelink.net/8qdpqmfc

https://pastelink.net/9km5gn49

https://rentry.co/vapefactory

https://dpaste.com/FUQXS76JF-preview

https://pastebin.com/04mkpDB3


https://notepadonline.co/share/70qmAs1669651083

https://pastefree.net/rWjydLk40qM

https://pastebin.freeswitch.org/view/9b57eed9#L4

https://paste.laravel.io/688daa1c-95be-4a23-91a1-416c1aa2a51c

https://privatebin.net/?7ee27902ae520446#5dmwsRS4W4fgfHTpS6A8nQo8mKyLHyMy35pLsdEFUg3D

https://0.0g.gg/?7226fa607132dcc8#4L7oTRLQAbKq4H4dCJKUCRamffi9aWAJZVsJqoLShYLz

https://0.jaegers.net/?d71fa6d60d16d9c4#7Ci3qwA6vzuK7ohDdPqTMkepkPewTYZeN2Z6dsvwf3y3

https://0.klowdee.host/?cc808aabc0dd0738#CYeEDv5hu2kxeXviC2Wwo7h8H5BGaYvHjed71nr65euA

https://0a0bin.klowdee.host/?f18fa4c110b9b729#3syGanFWJDhC2tT3ktbWmvMoz1B6kS4Nryc75gBP46aG

https://bin.0xfc.de/?04c4c9210605c990#2mNrfSFPSNiMhaBjnsv9oyjp1oUu6dm7iweJ7EgVETEL

https://bin.foss.wtf/?b27a17546ed2967f#59LVV9fiBsvGFvxbH2gstGYui8F9RUGqDCzo8SwRaHo4

https://bin.klowdee.host/?44fa044b95ec4ce8#3Cwx7MY9DQnr73jFyQRMtSEx7yAkoiPW3ZaSVMMVaVVa

https://cpaste.org/?b285fb0b8449f762#3eZGT84ufHHA8evrA7TiVD2XMqY33sGypqJKCtmsqAKi

https://luckvintage.com/?b6aa2187d87b5b5b#4MyEwLyQy3Vvf37jf8utvZ1NULhRq4ZxcvQniU9LcYJq

https://notebin.de/?b7de10af28186a8a#7HUVdbgJH9rbL46L8EECx5H4bk3MF1ui2QWwchBbSmzw

https://p.darklab.sh/?cf50217497eeae33#48HiHNt9GHoMeJGMUqE46j8UjfFhua3effjGt5h3qTjQ

https://kll.li/cw780

https://go.0xfc.de/s1a7r7

https://paste.hostux.net/?822a5f95af3db05d#4ZJRA66F7RUehyBWknzZpdxnGFFEW1Y66vLgp9pSL2Mc

https://paste.itefix.net/?cfc5e8027ceb23d9#4VZhAx7NzHAHKaoVY3DR3RJgzzWtgBwBuY1mAQ9qUeu7

https://paste.momobako.com/?b54710533275e10d#9hzSVLacr2GJvmkUdD2VNLSXfikJxdPgGo9FpsBmNMvJ

https://url.oelrichsgarcia.de/AMwB7

https://paste.ononoki.org/?6aac4bb7152ba76f#4rmak4Go7oUSessUpNtMccJGEiid6Axwuy4VaRCFPtVe

https://paste.ottertelecom.com/?ed368dcd2e0f3e4b#89hZMmJi3LTQyng5mm5J7uSq56TBUyoS9k7eLvzLAHvC

https://bhh.sh/6kv

https://justpaste.me/vapefactory

https://www.pastery.net/csjmje/

https://newtextdocument.com/t/vapefactory

https://www.zippyjot.com/note/88290

https://markdownpastebin.com/?id=a87386eca19e43daaceaed38cadd93c1

https://hastebin.com/quwaburiri.md

https://paste-bin.xyz/968218

https://nopaste.ml/?l=mrwn#XQAAAQDnAQAAAAAAAAAeHAPEVLS59lHh3xg/OQJcdvrR/U/ycPo2VIPTB2g5g8Xf3v9Di/NYf7K1aoBwxEWvaUiz2xGhkHA8Mp/R2IyT8KpMmUbNVcmHxITFXNsgKqIv1hRDigz47zJvZW3iGL85D2EuDE9cxVD+YLV2CLgxkDF+R7glyaaiV6Pm5MBJAholv6w3TKRjNhO0y7V2XJkEgSeu3rdXjPjBzz9F854nO7RKfQpgjv1PA+RqmQiWiZmAL3UkPJp33AEElJ/8phS+hzfLc6UMapKD/pqj6LGDJNZJi5aEsnIiMwQ29bychERkSJawkORymO/OB4m1EjdkbT30APJicH+7qzZiYocJ84TrgGIKr4gpRnbW1CGDhx67yhxlE+z/c40ZabsRx+uj8FShzQX8KxJcFVzDSctTm4SGT6ShtRah6HAXNEB5FJoXbH/9o8ml

https://snippet.host/egrzod

https://notes.io/q3CXc

http://paste.akingi.com/g5EEKUXr

http://paste.jp/2340b335/

https://pst.klgrth.io/paste/76vh9

https://paste.tuxcloud.net/?aa43b8a439474f4e#8wCMq5omoVJT9afkCsKEtMGdbS1MYYy8YbYP4sJbfKPc

https://pastebin.grey.pw/?eb7f9227f8f9c675#BkfKX9pm6vBGowxf6etgtp41kmKWQYmvqbTvdotFQe9b

https://pastebin.hot-chilli.net/?c4856edc9f75c3ec#DYE8CWiyRi9fvysdP9t5AriNnjbqtoWefMoRhGbhZt52

https://pastebin.linqhost.nl/?79e1ea7c8119baf6#7DnPowcnmoR32hKsT2MkMmvhycxuLnfyLuaktHw3rGR7

https://privatebin.at/?9f5afe906740f58a#AtuK5mpf5UNxDqwM7wVn6FQ3GCjA6fbC19zFhidfyjUE

https://privatebin.io/?0e28d362cd4ce612#J34S6ctSCh5HiZZGWUdpx36kyfHRqrh1KgJZPbqiookX

https://privatebin.net/?7f6bc481048e5b8b#3ZdBUUT2dS7Pk9sBsG9bkzJfm8Dk6BgemQttXGYiNy5W

https://privatebin.rockhost.se/?c1166fe766ea7487#DxwTJh5edJD4JCZhaFzH1U1i5NhsFF6tPBcDyYc9udBg

https://secrets.cebador.fr/?754c0492a4bdd103#DmzM2yiqtmpY95rxPhM8eso5KfRHU5FjhVBWqhsYYGEy

https://secrets.true.nl/?488ab298dcb02fce#4A2B7nEMMRN63WXAkUEY5LtoakxQXAUgNhkdZF93uts3

https://snip.dssr.ch/?0146ac45d8d6ffac#B8nkmXDzQqQ8f4gXWxzLXjduXWf8WFoPt3jRDkJ1pquW

https://zerobin.thican.net/?7fd683a533740ffa#Enwiu5mgU26Yp46DR4JKyDm32tcmKHhMM6UkWg55dqRq

https://u.07f.de/sbedo

https://6066.xyz/KY71C

https://paste.techbag.app/?bad2bb1088ef1781#4XDqEnMPuNywwKDvQscA3pNZr5Suyii8EUhfmYAdqwd9

https://bin.disroot.org/?34f408620dd08504#DX6rcUAGwMgiCZDCjbDNGFjPa1yWAtSiowgY3R6PyJSK

https://bin.garbaye.fr/?41119183d0c1484a#CAuUEi2dzYm28ZF9URukd44cf6aaBMmBWSAZmyANPBW3

https://bin.jae.fi/?dcd0702412de36ac#C1HKVZkhYzNhuqRSF9Hnho888kToK4GnzeYZb9UdWhW7

https://bin.namazso.eu/?6c3f328a0c069e1f#96Nz4xUEAJ3hzrgiCqojSS2RgEfV5RW19njnPAJHx3JQ

https://paste.4s3ti.net/?ef5fb8a0ffcbe709#EmcFKBWzYxdMvBJvJ8CPAJRDhCtSsLKszzaiftjjAM37

https://paste.copper.dedyn.io/?f52b421d6109b0cc#5fNmacCp72coPLdtz2faEr1aYjnpR4vmtrVHhfbhVEH2

https://paste.d-ku.de/?d07e085405265f7d#GRAdmq9uDjZXg5opCP3h36LTW5oAE1mZPpAFXUr89HVW

https://paste.dismail.de/?21b8d752e0dec48d#FUUzTPVYzxd3hBBdXHE4nc3F77mPAa7fai3gafY23c9d

https://paste.eccologic.net/?ab9d2f0462187994#5vjUsqhuGJshaPiscQwS4JvNfY72eta7fSrjmtJttxV2

https://paste.hackliberty.org/?a04ead16b6b8c312#4zpjbDFma7Miw2iVk8WqCYRGZazd12x72xU83rStsWZ

https://paste.rys.pw/?d1d4ac683b2f7e88#DmigSE23jeFfNkGN5RFu269CgYRGJV1Tt8QaGnyNnps6

https://paste.sethforprivacy.com/?1d6d069875eb2db9#9Nm4E7DNKKVh1b5SGboTgBnVBPCNRT2JaXiYqgTwNJfW

https://paste.systemli.org/?d90bc7e0a909554e#SGBUtKNVewU4VikTzYRyBkEXSWhGZCuVGbZ4hbN1TXn

https://paste.waays.fr/?aa425d0274bd796e#6DnyTu5mzV7pqjAkbyKe6X2S6HLTRjoXbceq34vhbVMG

https://pastebin.aquilenet.fr/?92de145104d2e458#4aFNoRvVpejtdq6Jna7ecdcJALMgbfYR5k27mvie66nA

http://pastebin.falz.net/2499575

https://0paste.com/436994

https://tech.io/snippet/p9dNUJz

https://tlabs.link/5awo1tf2

https://pastewith.me/?89fde2459aecba0e#7ynHu9kUBW1ABRvfSThfwKMkgu6eZeW8wofRdvrtsSB4

https://pb.fedi.tech/?894fbb8ba3003f76#HcnkPWzs5JbuXShSLLVvL7M2hWnHG2f5fpY4sH7Tn6y5

https://private.opendoor.fr/?9eb418f16baeb5c8#9HWLurWyxXZRnNEvaDTk415gZXUkdy5MM2GVbYJvESLU

https://private.rmconsulting.com/?f4594eab15556b7d#FX2rxTf4Ga1aFv1gnrBzpc4bmDwUzW8ngwVuFfqmXiGh

https://privatebin.jasonthai.me/?89793268fc239e37#8yUqzfKvpjX3NmV5LdquyVzS41nrfFECwfnYLEvJ6aSG

https://privatebin.jirlagun.com/?ec42065b71318070#8Q7oUK9QmsrRtnkDux8kJvX86PV3ArB2e8rS3DDMifYu

https://url.privatepastebin.com/1ad

https://pb.envs.net/?74f5d5a9bc465dbb#DsU4d7xfYnomPf31jCEPBQgzdmAkt5wHvsFxeykBBYJy

https://pastebin.24unix.net/?ad56dcbfa2d48988#8Ri45zN7FaTRHaLTkiFWNH3xC66n8AmrMoSFUZocYPqB

https://bin.byreqz.de/?e5a07954f69590d2#8fd1JscG5zQwFsj6dgaeSaCpL9HDGaWo41vpWsFDz56m

https://chobble.com/?814d9b4a4b1a7cef#sVZ7FYReqzh8J8NZkqjECvsxW8xM8EFkpia16NkWYpo

https://ots.ip-projects.de/?4556b6fe422e656d#EckKDsHfVcYZnTc1bvZXXWpHb8W9Ucx8TypADX8HupbA

https://p.ifxy.cc/?709fd4a770f0f9a1#2mY9t8Mkn5aNuwVMdi4y52MU3LakYS2VgtfdcPxzaHWq

https://paste.crabdance.com/?3be13ae9fe7ba44a#2K1KvTXTu3a5NnaxP4xCqm4hbUGU3rem9TyVdbtSUH2U

https://privatebin.lyndendoor.com/?6ab8deae13c2cfc7#7FD6rRqFteLMbJpLZifStLZCY4SvJYgaaJbSQNkKaaab

https://bin.acquia.com/?2ef0d31a8b9614c7#D8jEewoDsEcYUgPQtnALmtBV4wm5qFhR4g7zHTNhPyzH

https://pb.pc-sam.net/?40d680f27b67cbe2#pR1wspcNWWh9sZoteCHPQqRnP25SZJNKhowndZRpcPJ

https://bin.mycozy.space/?7a0fc665f69174a0#4jN5pUSx38GwGWiqEL6kVxNFdYD4vks9P4sKXWxYYXu7 

https://gitgd.com/?a7f84364b1b7b72e#7Rua3EQDiKziLC8fSkdZRoDBFEHstxY1qEsmTuU1xbAA

https://paste.cezeri.tech/?9148086a0f597547#FZmC95wNXmMspouQ31nkvqEZDa9M5Z6BDMzSRy2gEK13

https://paste.chapril.org/?1ad7ebf067dbed12#EV64GjoJdkz6wTiyvqLYEqunovXaZTZc6LGES5n8vD4t

https://paste.evolix.org/?0ee64a6e047f7768#2Zs8R3CNWzXysSGTRc2aqN4Hp4KdorHrL3BFmc5XUbiK

https://paste.ggc-project.de/?f9b94562a091fdfa#FbsV7UVc7vM2Q7ScoYDwNtbq2E1XUPmDs9hNLWs123Fk

https://paste.nolog.cz/?9313e29bc5d35fa7#38VHftE2hVz8KgjAv6uBWHAJkBHgST8sJKwooqHMbHwE

https://paste.ztn.sh/?b60f72c3aa63f186#5rHHdVqMwoLgsLYez5SvUn82sL9MM8hrRedbcA4MF9eS

https://pb.slipfox.xyz/?4925a178dc1214b1#CCr8N5eBwPmN5i2n7rrpEv5gej7qhB94NCM4orxme2Sr

https://postit.hadoly.fr/?a6fdd2be443110b7#F7mWqTyzJYzzcX3V95CDRy8h1QKAW7Femt2htEgE3Qp3