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Reviews of "Blood Transcriptomics Reveal Persistent SARS-CoV-2 RNA and Candidate Biomarkers in Long COVID Patients"

Reviewers: S Fourati (Northwestern University) | 📒📒📒 ◻️◻️ • I O Sirbu (University of Medicine and Pharmacy from Timisoara) | 📗📗📗📗◻️ • S Brüningk (University of Zurich) | 📒📒📒 ◻️◻️

Published onMar 12, 2024
Reviews of "Blood Transcriptomics Reveal Persistent SARS-CoV-2 RNA and Candidate Biomarkers in Long COVID Patients"

To read the original manuscript, click the link above.

Summary of Reviews: This study used blood digital transcriptomics in search of viral persistence and Long COVID diagnostic biomarkers. Their findings included showing systemic SARS-CoV-2 persistence for more than 2 years after acute COVID-19 infection. Furthermore, they identified a candidate two-gene biomarker (including FYN and SARS-CoV-2 antisense RNA) which classified Long COVID with good sensitivity and specificity. Reviewers posed concerns regarding sample size, the statistical methods used, and some lack of important details in the written report.

Reviewer 1 (Slim F…) | 📒📒📒 ◻️◻️

Reviewer 2 (Ioan Ovidiu S…) | 📗📗📗📗◻️

Reviewer 3 (Sarah B…) | 📒📒📒 ◻️◻️

RR:C19 Strength of Evidence Scale Key

📕 ◻️◻️◻️◻️ = Misleading

📙📙 ◻️◻️◻️ = Not Informative

📒📒📒 ◻️◻️ = Potentially Informative

📗📗📗📗◻️ = Reliable

📘📘📘📘📘 = Strong

To read the reviews, click the links below. 

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