Skip to main content
SearchLoginLogin or Signup

Reviews of "Single-cell RNA sequencing highlights a reduced function of natural killer and cytotoxic T cell in recovered COVID-19 pregnant women"

Reviewers: Claudine Irles (National Institute of Perinatology) | ๐Ÿ“’๐Ÿ“’๐Ÿ“’โ—ป๏ธโ—ป๏ธ โ€ข Suhas Sureshchandra (UC Irvine) | ๐Ÿ“’๐Ÿ“’๐Ÿ“’โ—ป๏ธโ—ป๏ธ

Published onSep 28, 2022
Reviews of "Single-cell RNA sequencing highlights a reduced function of natural killer and cytotoxic T cell in recovered COVID-19 pregnant women"
key-enterThis Pub is a Review of
Single-cell RNA sequencing highlights a reduced function of natural killer and cytotoxic T cell in recovered COVID-19 pregnant women
Description

AbstractPregnancy is a complex phenomenon during which women undergo immense immunological change throughout this period. Having an infection with the SARS-CoV-2 virus leads to an additional burden on the highly stretched immune response. Some studies suggest that age-matched pregnant women are more prone to SARS-CoV-2 infection compared with normal healthy (non-pregnant) women, while alternative evidence proposed that pregnant women are neither susceptible nor develop severe symptoms. This discrepancy in different findings regarding the immune responses of pregnant women infected with SARS-CoV-2 virus is not well understood. In this study, we investigated how SARS-CoV-2 viral infection could modulate the immune landscape during the active infection phase and recovery in pregnant females. Using flow cytometry, we identified that intermediate effector CD8+ T cells were increased in pregnant women who had recovered from COVID-19 as opposed to those currently infected. Similarly, an increase in CD4+ T helper cells (early or late) during the recovered phase was observed during the recovery phase compared with infected pregnant women or healthy pregnant women, whilst infected pregnant women had a reduced number of late effector CD4+ T cells. CD3+CD4- CD8-NKT cells that diminished during active infection in contrast to healthy pregnant women were significant increase in recovered COVID-19 recovered pregnant women. Further, our single-cell RNA sequencing data revealed that infection of SARS-CoV-2 had changed the gene expression profile of monocytes, CD4+ effector cells and antibody producing B cells in convalescent as opposed to healthy pregnant women. Additionally, several genes with cytotoxic function, interferon signalling type I & II, and pro- and anti-inflammatory functions in natural killer cells and CD8+ cytotoxic T cells were compromised in recovered patients compared with healthy pregnant women. Overall, our study highlights that SARS-CoV-2 infection deranged the adaptive immune response in pregnant women and could be implicated in pregnancy complications in ongoing pregnancies.

To read the original manuscript, click the link above.

Summary of Reviews: This study characterizes the immune landscape during active infection phase and recovery in pregnant females from COVID-19. Reviewers find the study potentially informative, with concerns over variability in gestation stage in different groups, and lack of functional follow-ups.

Reviewer 1 (Claudine Irles) | ๐Ÿ“’๐Ÿ“’๐Ÿ“’ โ—ป๏ธโ—ป๏ธ

Reviewer 2 (Suhas Sureshchandra) | ๐Ÿ“’๐Ÿ“’๐Ÿ“’ โ—ป๏ธโ—ป๏ธ

RR:C19 Strength of Evidence Scale Key

๐Ÿ“• โ—ป๏ธโ—ป๏ธโ—ป๏ธโ—ป๏ธ = Misleading

๐Ÿ“™๐Ÿ“™ โ—ป๏ธโ—ป๏ธโ—ป๏ธ = Not Informative

๐Ÿ“’๐Ÿ“’๐Ÿ“’ โ—ป๏ธโ—ป๏ธ = Potentially Informative

๐Ÿ“—๐Ÿ“—๐Ÿ“—๐Ÿ“—โ—ป๏ธ = Reliable

๐Ÿ“˜๐Ÿ“˜๐Ÿ“˜๐Ÿ“˜๐Ÿ“˜ = Strong

To read the reviews, click the links below.

Comments
11
?
lucifer donghua:

donghuastream.me stands out with its dark, mythological storyline and visually stunning animation. It masterfully blends traditional Chinese culture with modern themes, offering an engaging and immersive experience for fans of donghua.

?
Marian Lalipop:

Hello Kitty games online is a globally beloved character created by the Japanese company Sanrio. Known for her iconic red bow and simple yet charming design, Hello Kitty has become a cultural icon. She appears on a wide range of merchandise, from toys and clothing to accessories and home goods. Celebrated for her universal appeal and timeless charm, Hello Kitty continues to bring joy to fans of all ages around the world.

?
Marian Lalipop:

Run 1 ู„ุนุจุฉ ู…ู…ุชุนุฉ ูˆุฅุฏู…ุงู†ูŠุฉ ุญูŠุซ ูŠุชุญูƒู… ุงู„ู„ุงุนุจูˆู† ููŠ ุดุฎุตูŠุฉ ูุถุงุฆูŠุฉ ุชุชุญุฑูƒ ุนุจุฑ ุณู„ุณู„ุฉ ู…ู† ุงู„ุฃู†ูุงู‚ ูˆุงู„ู…ู†ุตุงุช ุงู„ุตุนุจุฉ. ู…ุน ุชุญูƒู…ุงุช ุจุณูŠุทุฉุŒ ูŠุฌุจ ุนู„ู‰ ุงู„ู„ุงุนุจูŠู† ุงู„ู‚ูุฒ ูˆุชุฌู†ุจ ุงู„ุนู‚ุจุงุชุŒ ู…ู…ุง ูŠุฎุชุจุฑ ุฑุฏูˆุฏ ุฃูุนุงู„ู‡ู… ูˆุฏู‚ุชู‡ู…. ู…ุณุชูˆูŠุงุชู‡ุง ุงู„ุตุนุจุฉ ูˆุงู„ู…ุชุฒุงูŠุฏุฉ ุชู‚ุฏู… ุชุญุฏูŠู‹ุง ู…ู…ุชุนู‹ุง ู„ุง ู†ู‡ุงูŠุฉ ู„ู‡.

Wordle Wordle:

I really don't want to read articles about COVID anymore, since this epidemic appeared it has changed my life a octordle lot but fortunately we have now controlled it and everything is okay back to normal like before.

?
TelecomYaar โ€Ž:
?
TelecomYaar โ€Ž:
?
miksol Linaks:

@spacebar clicker Possible consequences for maternal and foetal health may be uncovered by the study's results regarding the effect of pregnant women's immune systems.

?
reichel marcia:

The immunological responses of pregnant wordle today women infected with SARS-CoV-2 virus vary, which is unclear.

?
Roger Hayden:

This discrepancy in different findings regarding the immune responses of pregnant women infected with SARS-CoV-2 virus is not well understood trap the cat.

?
Sharase Hall:

The study's findings may provide insights into the impact of COVID-19 on the immune system of pregnant women and the potential implications for the health of both the mother and the developing fetus. However, it is important to note that the study's results should be interpreted with subway surfers caution and further research is needed to confirm the findings and determine their clinical significance.

?
laura lorde:

Thanks for the information, shell shockers will try to figure it out for more. Keep sharing such informative post keep suggesting such post.

?
Lynn Davenport:

RobTopGames made and put out Geometry Dash World, a free app that adds new levels and is backed by ads.