Skip to main content
SearchLoginLogin or Signup

Reviews of "Lipid droplets fuels SARS-CoV-2 replication and inflammatory response"

Reviewers: Ulrich Desselberger (University of Cambridge) | 📗📗📗📗 ◻️ • KJ Helbig, Ebony Alice Monson (La Trobe University) | 📒📒📒 ◻️ ◻️ • Prasert Auewarakul (Mahidol University) | 📒📒📒 ◻️ ◻️

Published onSep 21, 2020
Reviews of "Lipid droplets fuels SARS-CoV-2 replication and inflammatory response"
key-enterThis Pub is a Review of
Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators
Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators
Description

Viruses are obligate intracellular parasites that make use of the host metabolic machineries to meet their biosynthetic needs, identifying the host pathways essential for the virus replication may lead to potential targets for therapeutic intervention. The mechanisms and pathways explored by SARS-CoV-2 to support its replication within host cells are not fully known. Lipid droplets (LD) are organelles with major functions in lipid metabolism and energy homeostasis, and have multiple roles in infections and inflammation. Here we demonstrate that monocytes from COVID-19 patients have an increased LD accumulation compared to SARS-CoV-2 negative donors. In vitro, SARS-CoV-2 infection modulates pathways of lipid synthesis and uptake, as CD36, SREBP-1, PPARγ and DGAT-1 in human monocytes and triggered LD formation in different human cells. LDs were found in close apposition with SARS-CoV-2 proteins and double-stranded (ds)-RNA. The pharmacological modulation of LD formation by inhibition of DGAT-1 with A922500 significantly inhibited SARS-CoV-2 replication as well as reduced production of pro-inflammatory mediators. Taken together, we demonstrate the essential role of lipid metabolic reprograming and LD formation in SARS-CoV-2 replication and pathogenesis, opening new opportunities for therapeutic strategies to COVID-19.

To read the original manuscript, click the link above.

Summary of Reviews: This study claims infection-mediated lipid droplet biogenesis contributes to SARS-CoV-2 replication while suppressing lipid droplet formation restricts infection. However, these are not fully substantiated by the data offered due to lack of proper controls.

Reviewer 1 (Ulrich Desselberger) | 📗📗📗📗◻️

Reviewer 2 (KJ Helbig, Ebony Alice Monson) | 📒📒📒 ◻️◻️

Reviewer 3 (Prasert Auewarakul) | 📒📒📒 ◻️◻️

RR:C19 Strength of Evidence Scale Key

📕 ◻️◻️◻️◻️ = Misleading

📙📙 ◻️◻️◻️ = Not Informative

📒📒📒 ◻️◻️ = Potentially Informative

📗📗📗📗◻️ = Reliable

📘📘📘📘📘 = Strong

To read the reviews, click the links below. 

Comments
1
Vape Factory:

https://guides.co/g/disposable-vape

https://vapegator.newgrounds.com/

https://vapegator.newgrounds.com/news/post/1297980

https://app1.findit.com/roeenfldibykyyy/RightNow/summary-of-manners-and-places-to-smoke-a-vape/82aad332-4fea-4bbf-a4d0-e207ba6e70b8

https://www.theloop.com.au/project/vapecig/portfolio/disposable-vape/451084

https://meadd.com/vapecig/72462058

https://grow.tribe.so/post/news-of-vape-regulation-in-china-6308733430eeb3a5174685a8

https://tybbhopal.tribe.so/post/news-of-vape-regulation-in-china-6308734530eeb346c14685b5

https://grow.tribe.so/user/vape_factory

https://tybbhopal.tribe.so/user/vape_factory

https://musicschool.tribe.so/user/vape_factory

https://musicschool.tribe.so/post/are-electronic-cigarettes-harmless-630e072b08ddc1b15d7517c7

https://opensea.io/ecigator

https://www.livebinders.com/b/3249612

https://www.livebinders.com/play/play/3249612?tabid=8c419caa-064e-44f3-a8d9-575f569927fd

https://www.livebinders.com/play/play/3249612?tabid=b6a10d00-cfe1-4f51-ba44-2491d66c274e

https://www.livebinders.com/play/play/3249612?tabid=5a9cc993-9907-4091-b71c-6cd40875e4ba

https://www.livebinders.com/play/play/3249612?tabid=30fe5ffe-988e-4ed4-80a8-ea28a6962a2f

https://codepen.io/vapecig/pen/BarXddj

http://ubl.xml.org/blog/vapecig

https://issuu.com/vapecig/docs/how_to_choose_an_electronic_cigarette

https://create.piktochart.com/output/afda729ab2a2-e-cigarettes-and-real-cigarettes

https://www.edocr.com/user/vapecig

https://www.edocr.com/v/67b0erom/vapecig/how-to-choose-an-electronic-cigarette

https://www.edocr.com/v/2glrnzdj/vapecig/what-is-vape

https://vapeall.mystrikingly.com/

https://vapeall.mystrikingly.com/blog/do-youngsters-in-the-uk-vape

https://vapeall.mystrikingly.com/blog/types-of-starter-kit-devices

https://vapeall.mystrikingly.com/blog/vape-kits-for-starters-that-are-recommended

https://vapeall.mystrikingly.com/blog/a-beginner-s-guide-to-disposable-vapes

https://vape.static.app/

https://vapeecig.statuspage.io/

https://vapecig.blogs.sapo.pt/

https://vapecig.blogs.sapo.pt/is-it-safer-to-vape-with-a-disposable-370

https://vapecig.blogs.sapo.pt/what-is-the-most-popular-disposable-852

https://vapecig.blogs.sapo.pt/what-are-top-5-disposable-vapes-1346

https://vapecig.blogs.sapo.pt/are-there-toxic-metals-in-disposable-1928

http://vapenew.e-monsite.com/

https://vapecig.arwebo.com/37068033/how-to-choose-an-e-cigarette

https://vapecig.arwebo.com/

https://vapecig.arwebo.com/37067971/what-makes-a-good-cosmetic-e-cigarette

https://vapecig.bsite.net/

http://vapelife.atwebpages.com/

https://vape-life.my-free.website/

https://vape-life.my-free.website/blog/post/2159519/pod-type-vape-is-a-hot-item

https://vape-life.my-free.website/blog/post/2159518/where-can-i-purchase-pod-type-vape

https://vape-life.my-free.website/blog/post/2159517/what-is-a-pod-type-of-vape

http://vapelife.bravesites.com/blog

http://vapelife.bravesites.com/entries/general/advantages-and-disadvantages-of-the-pod-type-vape

http://vapelife.bravesites.com/entries/general/what-vapde-devices-do-you-recommend-

http://vapelife.bravesites.com/entries/general/pod-type-vape-is-a-hot-item-

https://vape-life.mozellosite.com/

https://vape-life.mozellosite.com/blog/params/post/4185791/the-design-and-mechanism-of-electronic-cigarettes

https://vape-life.mozellosite.com/blog/params/post/4185789/smoking-cessation-using-e-cigarettes-as-well-as-research

https://vape-life.mozellosite.com/blog/params/post/4185787/

https://vapecig.bcz.com/

https://vapecig.bcz.com/2022/11/15/how-to-choose-a-disposable-vape/

https://vapecig.bcz.com/2022/11/30/vape-kits-for-starters-that-are-recommended/

https://china-vape-manufacturer.jimdosite.com/

https://vapecigreview.wordpress.com/

https://vapecigreview.wordpress.com/2022/11/29/the-vape-market-in-europe-and-the-u-s-and-europe/

https://vapecigreview.wordpress.com/2022/11/29/quit-smoking-with-electronic-cigarettes/

https://vapecigreview.wordpress.com/2022/11/29/differences-between-e-cigarettes-and-real-cigarettes/

https://vapecigreview.wordpress.com/2022/11/29/the-information-about-harm-from-vaping-is-a-lie/

https://vapecigreview.wordpress.com/2022/11/29/the-difference-between-shisha-and-vape/

https://sites.google.com/view/vapeecig/home

https://sites.google.com/view/vapeecig/what-is

https://vape-ecig.yolasite.com/minors/

https://ameblo.jp/vapecig/

https://ameblo.jp/vapecig/entry-12777111038.html

https://vapeall.godaddysites.com/

https://ecigatornew.wixsite.com/vape-all

https://ecigatornew.wixsite.com/vape-all/post/vape-kits-for-starters-that-are-recommended

https://ecigatornew.wixsite.com/vape-all/post/do-youngsters-in-the-uk-vape

https://ecigatornew.wixsite.com/vape-all/post/can-you-legally-vape-in-public-areas-across-the-uk

https://vapeall.company.site/

https://www.dibiz.com/ecigatornew