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Reviews of "Three-dose vaccination-induced immune responses protect against SARS-CoV-2 Omicron-BA.2"

Reviewers: Claudio Acuña (University of Santiago, Chile) | 📗📗📗📗◻️ • Cássia Terrassani Silveira (University of São Paulo | 📒📒📒◻️◻️

Published onJun 08, 2022
Reviews of "Three-dose vaccination-induced immune responses protect against SARS-CoV-2 Omicron-BA.2"

To read the original manuscript, click the link above.

Summary of Reviews: This preprint investigates the efficacy of 2/3 dose regimes of vaccines against Omicron BA.2 infection. Reviewers overall find this study informative, but highlight technical issues, and stylistic issues of results, that impact the conclusions drawn from the presented data.

Reviewer 1 (Claudio Acuña) | 📗📗📗📗◻️

Reviewer 2 (Cássia Terrassani Silveira) | 📒📒📒 ◻️◻️

RR:C19 Strength of Evidence Scale Key

📕 ◻️◻️◻️◻️ = Misleading

📙📙 ◻️◻️◻️ = Not Informative

📒📒📒 ◻️◻️ = Potentially Informative

📗📗📗📗◻️ = Reliable

📘📘📘📘📘 = Strong

To read the reviews, click the links below.


Comments
6
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As we navigate through the evolving landscape of the pandemic, the shift from two to three doses may play a pivotal role in fortifying our immune defenses, especially against formidable variants like Omicron-BA.2. This dynamic response underscores the importance of updating vaccination strategies to align with the ever-changing virus.

The temporal aspect is crucial in this context, emphasizing the need to consider the calendar of events. Understanding the duration of immune protection and its potential waning over time is essential for informed public health decisions. Continuous research and surveillance will be necessary to assess the long-term efficacy of these three-dose regimens and to anticipate any challenges posed by future variants that might appear on the calendar.

As we interpret this positive development, it's paramount to recognize that the calendar for vaccination campaigns remains a key tool in our efforts to control the spread of the virus. Increasing vaccine coverage and maintaining a proactive vaccination calendar are integral components of our collective response to the ongoing pandemic, ensuring a comprehensive defense against current and potential future threats.

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Danilo Zanna:

Templates: This summary provides helpful context about the key findings and limitations of the preprint evaluating two- and three-dose vaccine regimens against Omicron BA.2 infection. As the reviewers note, while this study does offer useful real-world data points, there are some technical and stylistic issues in the data analysis and presentation of results that constrain the conclusions that can be definitively drawn.

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