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Reviews of " SARS-CoV-2 Omicron BA.2.12.1, BA.4, and BA.5 Subvariants Evolved to Extend Antibody Evasion"

Reviewer: N Landau (NYU) |๐Ÿ“˜๐Ÿ“˜๐Ÿ“˜๐Ÿ“˜๐Ÿ“˜

Published onAug 02, 2022
Reviews of " SARS-CoV-2 Omicron BA.2.12.1, BA.4, and BA.5 Subvariants Evolved to Extend Antibody Evasion"
key-enterThis Pub is a Review of
SARS-CoV-2 Omicron BA.2.12.1, BA.4, and BA.5 subvariants evolved to extend antibody evasion
SARS-CoV-2 Omicron BA.2.12.1, BA.4, and BA.5 subvariants evolved to extend antibody evasion
Description

Abstract The Omicron subvariant BA.2 accounts for a large majority of the SARS-CoV-2 infection worldwide today1. However, its recent descendants BA.2.12.1 and BA.4/5 have surged dramatically to become dominant in the United States and South Africa, respectively2,3. That these novel Omicron subvariants carry additional mutations in their spike proteins raises concerns that they may further evade neutralizing antibodies, thereby further compromising the efficacy of our COVID-19 vaccines and therapeutic monoclonals. We now report findings from a systematic antigenic analysis of these surging Omicron subvariants. BA.2.12.1 is only modestly (1.8-fold) more resistant to sera from vaccinated and boosted individuals than BA.2. On the other hand, BA.4/5 is substantially (4.2-fold) more resistant and thus more likely to lead to vaccine breakthrough infections. Mutation at spike residue L452 found in both BA.2.12.1 and BA.4/5 facilitates escape from some antibodies directed to the so-called Class 2 and Class 3 regions of the receptor-binding domain (RBD)4. The F486V mutation found in BA.4/5 facilitates escape from certain Class 1 and Class 2 antibodies to the RBD but compromises the spike affinity for the cellular receptor ACE2. The R493Q reversion mutation, however, restores receptor affinity and consequently the fitness of BA.4/5. Among therapeutic antibodies authorized for clinical use, only bebtelovimab (LY-COV1404) retains full potency against both BA.2.12.1 and BA.4/5. The Omicron lineage of SARS-CoV-2 continues to evolve, successively yielding subvariants that are not only more transmissible but also more evasive to antibodies.

To read the original manuscript, click the link above.

Reviewer 1 (Nathaniel Lโ€ฆ) |๐Ÿ“˜๐Ÿ“˜๐Ÿ“˜๐Ÿ“˜๐Ÿ“˜

RR:C19 Strength of Evidence Scale Key

๐Ÿ“• โ—ป๏ธโ—ป๏ธโ—ป๏ธโ—ป๏ธ = Misleading

๐Ÿ“™๐Ÿ“™ โ—ป๏ธโ—ป๏ธโ—ป๏ธ = Not Informative

๐Ÿ“’๐Ÿ“’๐Ÿ“’ โ—ป๏ธโ—ป๏ธ = Potentially Informative

๐Ÿ“—๐Ÿ“—๐Ÿ“—๐Ÿ“—โ—ป๏ธ = Reliable

๐Ÿ“˜๐Ÿ“˜๐Ÿ“˜๐Ÿ“˜๐Ÿ“˜ = Strong

To read the reviews, click the links below.ย 


Comments
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https://cursedmetal.com/blogs/77701/Quit-smoking-with-electronic-cigarettes

https://globuzzer.mn.co/members/12637002

https://globuzzer.mn.co/posts/26607803

https://stemfemmes.mn.co/members/15010520

https://stemfemmes.mn.co/posts/about-me-32307820

https://stemfemmes.mn.co/posts/is-vaping-harder-to-quit-than-smoking

https://topbazz.com/vapecig

https://topbazz.com/post/7037_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://topbazz.com/read-blog/547

https://topbazz.com/read-blog/549

https://topbazz.com/read-blog/550

https://community.fyers.in/user/vape_factory

https://www.ekademia.pl/@ecigatornew/post/is-2-nicotine-a-lot-in-a-vape

https://www.ekademia.pl/@ecigatornew/blog

https://www.ekademia.pl/@ecigatornew/post/why-amazon-does-not-sell-vapes

https://www.ekademia.pl/@ecigatornew/post/how-much-should-a-beginner-vape

https://kbb-hub.mn.co/members/13924142

https://kbb-hub.mn.co/posts/about-me-29644806

https://kbb-hub.mn.co/posts/29644865

https://friendtalk.mn.co/members/13813267

https://friendtalk.mn.co/posts/what-is-a-vape

https://www.fuzia.com/article_detail/776046/10-surprising-benefits-of-using-disposable-vapes

https://uberant.com/article/1901623-the-best-disposable-vape-brands-to-try-in-2023/