Skip to main content
SearchLoginLogin or Signup

Reviews of " SARS-CoV-2 Omicron BA.2.12.1, BA.4, and BA.5 Subvariants Evolved to Extend Antibody Evasion"

Reviewer: N Landau (NYU) |📘📘📘📘📘

Published onAug 02, 2022
Reviews of " SARS-CoV-2 Omicron BA.2.12.1, BA.4, and BA.5 Subvariants Evolved to Extend Antibody Evasion"
key-enterThis Pub is a Review of
SARS-CoV-2 Omicron BA.2.12.1, BA.4, and BA.5 subvariants evolved to extend antibody evasion
SARS-CoV-2 Omicron BA.2.12.1, BA.4, and BA.5 subvariants evolved to extend antibody evasion
Description

Abstract The Omicron subvariant BA.2 accounts for a large majority of the SARS-CoV-2 infection worldwide today1. However, its recent descendants BA.2.12.1 and BA.4/5 have surged dramatically to become dominant in the United States and South Africa, respectively2,3. That these novel Omicron subvariants carry additional mutations in their spike proteins raises concerns that they may further evade neutralizing antibodies, thereby further compromising the efficacy of our COVID-19 vaccines and therapeutic monoclonals. We now report findings from a systematic antigenic analysis of these surging Omicron subvariants. BA.2.12.1 is only modestly (1.8-fold) more resistant to sera from vaccinated and boosted individuals than BA.2. On the other hand, BA.4/5 is substantially (4.2-fold) more resistant and thus more likely to lead to vaccine breakthrough infections. Mutation at spike residue L452 found in both BA.2.12.1 and BA.4/5 facilitates escape from some antibodies directed to the so-called Class 2 and Class 3 regions of the receptor-binding domain (RBD)4. The F486V mutation found in BA.4/5 facilitates escape from certain Class 1 and Class 2 antibodies to the RBD but compromises the spike affinity for the cellular receptor ACE2. The R493Q reversion mutation, however, restores receptor affinity and consequently the fitness of BA.4/5. Among therapeutic antibodies authorized for clinical use, only bebtelovimab (LY-COV1404) retains full potency against both BA.2.12.1 and BA.4/5. The Omicron lineage of SARS-CoV-2 continues to evolve, successively yielding subvariants that are not only more transmissible but also more evasive to antibodies.

To read the original manuscript, click the link above.

Reviewer 1 (Nathaniel L…) |📘📘📘📘📘

RR:C19 Strength of Evidence Scale Key

📕 ◻️◻️◻️◻️ = Misleading

📙📙 ◻️◻️◻️ = Not Informative

📒📒📒 ◻️◻️ = Potentially Informative

📗📗📗📗◻️ = Reliable

📘📘📘📘📘 = Strong

To read the reviews, click the links below. 


Comments
1
Vape Factory:

https://linevoom.line.me/post/1166176315561563552

https://coub.com/ecigator

https://sway.office.com/M5DCGkdFqRLzFQmb?ref=Link

https://www.homify.in/ideabooks/9128064/what-is-a-vape

https://unsplash.com/@vapecig

https://bookmarkswing.com/story13707746/vape-wholesale-ecig-manufacturer-factory

https://social.msdn.microsoft.com/Profile/Vape%20Factory

https://community.dynamics.com/members/vape-factory

https://community.powerbi.com/t5/user/viewprofilepage/user-id/475172

https://social.technet.microsoft.com/profile/vape%20factory/

https://band.us/band/88711848/post/1

https://band.us/band/88711848

https://www.gog.com/u/vapecig

https://gab.com/vapecig

https://gab.com/vapecig/posts/108900503280340362

https://vapecignew.blogspot.com/

https://vapecignew.blogspot.com/2022/08/people-who-are-addicted-to-electronic.html

https://vapecignew.blogspot.com/2022/11/what-is-electronic-cigarette.html

https://feedly.com/i/entry/fMe7/G3F2H0GZKZqc985OThfnRZ20w3IYeiFP7W28UA=_181aede9e10:102487c:37ab6f60

https://list.ly/i/8074989

https://www.pearltrees.com/matthewma

https://padlet.com/ecigatornew/vapecigarette

https://padlet.com/ecigatornew/vapecigarette/wish/2401482710

https://www.kdpcommunity.com/s/profile/0058V00000DRnLz?language=en_US

https://about.me/vapeecig/

https://www.instructables.com/member/ecigatornew/

https://www.deviantart.com/ecigator

https://www.deviantart.com/ecigator/art/History-Of-Electronic-Cigarette-428511854

https://www.minds.com/vapecig/

https://www.minds.com/groups/profile/1444201952551374863/feed

https://medium.com/@ecigatornew

https://vapecignew.livejournal.com/

https://vapecignew.livejournal.com/profile

https://vapecignew.livejournal.com/621.html

https://vapecignew.livejournal.com/503.html

https://vapecignew.livejournal.com/775.html

https://waoop.com/read-blog/14471

https://waoop.com/vaporcig

https://www.vsv7.com/read-blog/38579

https://www.vsv7.com/vaporecig

https://www.vsv7.com/post/92465_https-ecigator-com.html

https://www.myshareshow.com/read-blog/33658

https://www.myshareshow.com/vaporecig

https://www.myshareshow.com/post/79494_https-ecigator-com.html

http://networks786.ovh/read-blog/45206

http://networks786.ovh/vaporecig

http://networks786.ovh/post/92097_https-ecigator-com.html

https://somee.social/ecigator

https://somee.social/posts/680744

https://www.mycutiepies.com/vaporecig

https://www.mycutiepies.com/post/40084_https-ecigator-com.html

https://www.themetwallynetwork.com/vaporecig

https://www.themetwallynetwork.com/post/17532_https-ecigator-com.html

https://wanzani.com/vaporecig

https://wanzani.com/post/191015_https-ecigator-com.html

https://www.menagerie.media/read-blog/11384

https://www.menagerie.media/vaporecig

https://huduma.social/vapecig

https://huduma.social/posts/197902

https://gezelligkletsen.nl/read-blog/7879

https://gezelligkletsen.nl/vaporecig

https://gezelligkletsen.nl/post/16187_https-ecigator-com.html

https://theavtar.com/read-blog/8457

https://theavtar.com/vaporecig

https://theavtar.com/post/18490_https-ecigator-com.html

https://prosface.com/blogs/40695/People-who-are-addicted-to-electronic-cigarettes

https://prosface.com/pages/vapecignew

https://prosface.com/posts/40696

http://anonimsocial.r91601v6.beget.tech/blogs/1384/Can-minors-buy-e-cigarettes

http://anonimsocial.r91601v6.beget.tech/pages/vaporecig

http://anonimsocial.r91601v6.beget.tech/posts/1385

https://priti-nag.tribe.so/user/vape_factory

https://priti-nag.tribe.so/post/are-electronic-cigarettes-harmless-630e21d305f1aac90e1ebbb9

https://community.telecomdrive.com/user/vape_factory

https://community.telecomdrive.com/question/vape-electronic-cigarette-disposable-vape-pen-ecig-manufacturer-and-vape-fa--6310dc3446430e158a0a347c

https://everyonespace.tribe.so/user/vape_factory

https://everyonespace.tribe.so/post/how-to-choose-an-electronic-cigarette-6310ab15513b775575ef9b3e

https://www.vevioz.com/vaporecig

https://www.vevioz.com/post/275412_https-ecigator-com.html

https://hiqy.in/vaporecig

https://hiqy.in/post/44731

https://workplace.vidcloud.io/social/read-blog/92892

https://workplace.vidcloud.io/social/read-blog/92899

https://talkotive.com/read-blog/77487

https://talkotive.com/read-blog/77489

https://linkspreed.com/read-blog/138146

https://linkspreed.com/read-blog/138151

https://www.pittsburghtribune.org/read-blog/8929

https://www.pittsburghtribune.org/read-blog/8931

https://respeak.net/read-blog/49134

https://respeak.net/read-blog/49135

https://social.x-vendor.com/read-blog/65424

https://social.x-vendor.com/read-blog/65428

https://us.eurl.live/health/what-are-the-top-5-disposable-vapes

https://amazonsale.io/read-blog/5479

https://www.timessquarereporter.com/others/is-it-cheaper-to-buy-disposable-vapes-online

https://reviewsconsumerreports.net/business/who-will-ship-vape-products

https://www.pdf24x7.com/pdf/is-vape-worse-than-smoking

https://edu.pittsburghtribune.org/ebooks/what-s-the-best-brand-of-vape

https://www.nasseej.net/blogs/1415/How-to-Choose-an-Electronic-Cigarette

https://www.nasseej.net/posts/1416

https://www.hypebunch.com/vapecig

https://www.hypebunch.com/post/54248_https-ecigator-com-vape-ecig-health-buy-best.html

https://corosocial.com/vapecig

https://corosocial.com/read-blog/164827

https://corosocial.com/read-blog/164828

https://corosocial.com/read-blog/164829

https://www.lawcodev.com/vapecig

https://www.lawcodev.com/post/250494_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://www.lawcodev.com/vaporecig

https://www.lawcodev.com/read-blog/236579

https://www.lawcodev.com/read-blog/236580

https://www.lawcodev.com/read-blog/236581

https://www.palpodia.com/vapecig

https://www.palpodia.com/post/62079_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://www.palpodia.com/read-blog/18519

https://www.palpodia.com/read-blog/18520

https://www.palpodia.com/read-blog/18521

https://friend007.com/read-blog/36015

https://friend007.com/vapecig

https://friend007.com/post/193096_https-ecigator-com.html

https://www.bhimchat.com/vaporecig

https://www.bhimchat.com/vapecig

https://www.bhimchat.com/post/76334_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://www.bhimchat.com/post/76336_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://pharmatalk.org/read-blog/28528

https://pharmatalk.org/vapecig

https://pharmatalk.org/post/78393_https-ecigator-com.html

https://www.camfect.com/read-blog/15048

https://www.camfect.com/post/751902_https-ecigator-com.html

https://www.camfect.com/vapecig

https://community.tccwpg.com/vapecig

https://community.tccwpg.com/vaporecig

https://community.tccwpg.com/read-blog/147468

https://www.xaphyr.com/vapecig

https://www.xaphyr.com/pages/ecignew

https://www.xaphyr.com/blogs/180526/Types-of-Vape

https://www.xaphyr.com/blogs/228151/What-is-the-most-popular-vape-product

https://www.sholltna.com/read-blog/698

https://www.sholltna.com/post/1421_https-ecigator-com.html

https://www.sholltna.com/vapecig

https://www.emazoo.com/blogs/329733/How-to-Choose-an-Electronic-Cigarette

https://www.emazoo.com/vapecig

https://www.emazoo.com/posts/329734

https://www.addonface.com/vapecig

https://www.addonface.com/post/35148_https-ecigator-com.html

https://addandclick.com/read-blog/91440

https://addandclick.com/vapecig

https://addandclick.com/post/247273_https-ecigator-com.html

https://community.wongcw.com/vapecig

https://community.wongcw.com/posts/257048

https://community.wongcw.com/pages/ecignew

https://community.wongcw.com/blogs/257050/What-are-the-four-precautions-when-using-a-vape

https://community.wongcw.com/blogs/257051/How-to-use-a-vape-to-enjoy-it-more

https://community.wongcw.com/blogs/257053/Here-we-will-introduce-the-basic-usage-of-each-type

https://bumppy.com/tm/vapecig

https://bumppy.com/tm/vaporecig

https://www.rolonet.com/posts/177913

https://www.rolonet.com/vapecig

https://www.rolonet.com/pages/vaporcig

https://www.rolonet.com/blogs/177915/Vape-situation-in-Indonesia

https://www.rolonet.com/blogs/179932/Basic-Structure-of-Vape

https://www.as7abe.com/wall/blogs/post/12959

https://www.as7abe.com/wall/blogs/post/12960

https://www.as7abe.com/wall/blogs/post/12961

https://www.exoltech.ps/blogs/post/22823

https://www.exoltech.ps/blogs/post/22824

https://www.globhy.com/read-blog/7111

https://www.globhy.com/vapecig

https://www.globhy.com/post/11660_https-ecigator-com.html

https://community.sprintally.com/vapecig

https://community.sprintally.com/post/69761_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://community.sprintally.com/read-blog/16050

https://community.sprintally.com/vaporecig

https://community.sprintally.com/post/69763_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

http://socialnetwork.linkz.us/vapefactory

http://socialnetwork.linkz.us/posts/40163

http://socialnetwork.linkz.us/pages/vaporecig

http://socialnetwork.linkz.us/blogs/40165/What-are-the-four-precautions-when-using-a-vape

http://socialnetwork.linkz.us/blogs/40166/I-want-to-enjoy-vape-in-a-box

http://socialnetwork.linkz.us/blogs/40167/What-is-a-VAPE

https://wiwonder.com/vapecig

https://wiwonder.com/post/194507_https-ecigator-com.html

https://blacksnetwork.net/vapecig

https://blacksnetwork.net/post/64097_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://blacksnetwork.net/vaporecig

https://www.buzzbii.com/vapecig

https://www.buzzbii.com/post/290480_https-ecigator-com.html

https://lifesspace.com/vapecig

https://lifesspace.com/post/144449_https-ecigator-com.html

https://www.unitymix.com/vapecig

https://www.unitymix.com/vaporecig

https://www.unitymix.com/post/71615_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://hunch.lighthouseapp.com/users/1278184

https://fixholdandflip.lighthouseapp.com/projects/159773-dyebold/tickets/10-differences-between-e-cigarettes-and-real-cigarettes

https://fixholdandflip.lighthouseapp.com/projects/159773-dyebold/tickets/11-vape-factory

https://vape.lighthouseapp.com/projects/160007/quit-smoking-with-electronic-cigarettes

https://uconnect.ae/vapecig

https://uconnect.ae/post/32328_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://uconnect.ae/vaporecig

https://degentevakana.com/users/view/41544

https://degentevakana.com/blogs/view/136969

https://degentevakana.com/blogs/view/136981

https://buddybio.com/vapecig

https://buddybio.com/vaporecig

https://buddybio.com/post/100459_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://buddybio.com/read-blog/37380

https://social.kubo.chat/vapecig

https://social.kubo.chat/post/16392_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://social.kubo.chat/vaporecig

https://social.kubo.chat/post/16393_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://social.kubo.chat/read-blog/11286

https://social.kubo.chat/read-blog/12158

https://actsfile.com/read-blog/24019

https://actsfile.com/vapecig

https://actsfile.com/post/38704_https-ecigator-com.html

https://teachin.id/angelauy

https://teachin.id/posts/132759

https://teachin.id/blogs/132760/Let-s-get-the-basics-of-vape

http://www.barberlife.com/vapecig

http://www.barberlife.com/post/137727_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

http://www.barberlife.com/vaporecig

http://www.barberlife.com/read-blog/96666

http://www.barberlife.com/read-blog/96667

http://www.barberlife.com/read-blog/96668

https://shapshare.com/read-blog/178392

https://shapshare.com/vapecig

https://shapshare.com/post/297463_https-ecigator-com.html

https://goodshape1.com/read-blog/39424

https://goodshape1.com/vapecig

https://goodshape1.com/post/92637_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://goodshape1.com/vaporecig

https://facethai.net/vapecig

https://facethai.net/post/128834_https-ecigator-com.html

https://expressafrica.et/vapecig

https://expressafrica.et/post/121663_https-ecigator-com.html

https://demo.wowonder.com/vapecig

https://demo.wowonder.com/post/412797_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://demo.wowonder.com/vaporecig

https://wo.barataa.com/vapecig

https://wo.barataa.com/read-blog/108702

https://wo.barataa.com/read-blog/108708

https://wo.barataa.com/read-blog/108714

https://www.cyberpinoy.net/vapecig

https://www.cyberpinoy.net/post/6090_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://www.cyberpinoy.net/read-blog/5093

https://www.cyberpinoy.net/read-blog/5094

https://www.cyberpinoy.net/read-blog/5095

https://www.speakfreelee.com/vapecig

https://www.speakfreelee.com/post/36922_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://www.merexpression.com/vapecig

https://www.merexpression.com/post/144782_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://www.merexpression.com/read-blog/76898

https://www.merexpression.com/read-blog/76899

https://www.merexpression.com/read-blog/76900

https://socialmodem.com/1675956120339436_593

https://4african.com/vapecig

https://4african.com/post/1589_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://4african.com/read-blog/1073

https://4african.com/read-blog/1074

https://4african.com/read-blog/1075

https://www.chumsay.com/1676012290389810_5101

https://www.chumsay.com/post/17075_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://advpr.net/vapecig

https://advpr.net/post/51203_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://advpr.net/read-blog/49628

https://advpr.net/read-blog/49631

https://advpr.net/read-blog/49632

https://assignmento.org/vapecig

https://assignmento.org/post/7348_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://assignmento.org/read-blog/1986

https://assignmento.org/read-blog/1987

https://assignmento.org/read-blog/1988

https://blue.et/1675959939817498_5954

https://blue.et/post/16729_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://blue.et/read-blog/997

https://blue.et/read-blog/998

https://blue.et/read-blog/999

https://www.nhlfriends.com/vapecig

https://www.nhlfriends.com/post/21734_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://www.nhlfriends.com/read-blog/6780

https://www.nhlfriends.com/read-blog/6781

https://www.nhlfriends.com/read-blog/6782

https://www.jointcorners.com/vapecig

https://www.jointcorners.com/post/14208_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://www.jointcorners.com/read-blog/9767

https://www.jointcorners.com/read-blog/9768

https://www.jointcorners.com/read-blog/9769

https://kryza.network/vapecig

https://kryza.network/post/15411_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://socialcreditu.com/vapecig

https://socialcreditu.com/post/172085_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://www.truthsocialviet.com/vapecig

https://www.truthsocialviet.com/post/40731_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://www.truthsocialviet.com/read-blog/28197

https://www.truthsocialviet.com/read-blog/28201

https://www.truthsocialviet.com/read-blog/28202

https://mysportsgo.com/profile/vapecig

https://mysportsgo.com/profile/vapecig/action_id/443287

https://mysportsgo.com/Blog/1326/vape

https://mysportsgo.com/Blog/1327/why-should-i-choose-a-disposable-vape-pen

https://mysportsgo.com/Blog/1328/do-disposable-vape-get-you-high

https://www.vkay.net/vapecig

https://www.vkay.net/post/2563_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://www.vkay.net/read-blog/2299

https://www.vkay.net/read-blog/2300

https://www.vkay.net/read-blog/2301

https://www.noifias.it/vapecig

https://friendstrs.com/vapecig

https://friendstrs.com/post/8069_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://www.voyage-to.me/vapecig

https://www.voyage-to.me/post/54154_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://uchat.umaxx.tv/vapecig

https://uchat.umaxx.tv/post/64428_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://uchat.umaxx.tv/read-blog/51945

https://uchat.umaxx.tv/read-blog/51946

https://uchat.umaxx.tv/read-blog/51947

https://cursedmetal.com/vapecig

https://cursedmetal.com/posts/72573

https://cursedmetal.com/pages/vapecig

https://cursedmetal.com/blogs/72574/How-to-Use-a-Vape

https://cursedmetal.com/blogs/77701/Quit-smoking-with-electronic-cigarettes

https://globuzzer.mn.co/members/12637002

https://globuzzer.mn.co/posts/26607803

https://stemfemmes.mn.co/members/15010520

https://stemfemmes.mn.co/posts/about-me-32307820

https://stemfemmes.mn.co/posts/is-vaping-harder-to-quit-than-smoking

https://topbazz.com/vapecig

https://topbazz.com/post/7037_ecigator-is-one-of-the-well-known-vape-brands-spun-off-from-giftsoar-technology.html

https://topbazz.com/read-blog/547

https://topbazz.com/read-blog/549

https://topbazz.com/read-blog/550

https://community.fyers.in/user/vape_factory

https://www.ekademia.pl/@ecigatornew/post/is-2-nicotine-a-lot-in-a-vape

https://www.ekademia.pl/@ecigatornew/blog

https://www.ekademia.pl/@ecigatornew/post/why-amazon-does-not-sell-vapes

https://www.ekademia.pl/@ecigatornew/post/how-much-should-a-beginner-vape

https://kbb-hub.mn.co/members/13924142

https://kbb-hub.mn.co/posts/about-me-29644806

https://kbb-hub.mn.co/posts/29644865

https://friendtalk.mn.co/members/13813267

https://friendtalk.mn.co/posts/what-is-a-vape

https://www.fuzia.com/article_detail/776046/10-surprising-benefits-of-using-disposable-vapes

https://uberant.com/article/1901623-the-best-disposable-vape-brands-to-try-in-2023/