Reviews of "Germline-targeting Chimpanzee SIV Envelopes Induce V2-apex Broadly Neutralizing-like B Cell Precursors in a Rhesus Macaque Infection Model"

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Summary of Reviews: This preprint analyzes B cell and antibody responses in macaques infected with SCIVs expressing wildtype or germline-targeting Env. Reviewers provided positive feedback on the rationale, methods, and findings. They recognized the novelty of using SCIVs to evaluate immunogen design strategies for eliciting V2-apex bnAbs against HIV-1. Germline-targeting SCIVs elicited more B cell lineages with features resembling known V2-apex bnAb precursors than wildtype SCIV, but neutralization breadth did not develop, highlighting challenges in recapitulating bnAb maturation. Reviewers suggested experiments to strengthen conclusions about V2-apex specificity and relating antibody features to function. They deemed the preprint potentially informative pending revisions addressing limitations around conclusively demonstrating V2-apex specificity and relating antibody features to properties.

Reviewer 1 (Cynthia D…) | 📗📗📗📗◻️

Reviewer 2 (Anonymous) | 📒📒📒 ◻️◻️

Reviewer 3 (Suvadip M… & Ryan K…) | 📒📒📒 ◻️◻️

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