Skip to main content
SearchLoginLogin or Signup

Reviews of: "Zinc pyrithione is a potent inhibitor of PLPro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication"

Reviewers: Momoh Yakubu (Texas Southern University) | πŸ“˜πŸ“˜πŸ“˜πŸ“˜πŸ“˜ β€’ Tommaso Filippini (University of Modena and Reggia Emilia) | πŸ“—πŸ“—πŸ“—πŸ“—β—»οΈ

Published onMar 31, 2022
Reviews of: "Zinc pyrithione is a potent inhibitor of PLPro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication"
key-enterThis Pub is a Review of
Zinc pyrithione is a potent inhibitor of PL<sup>Pro</sup> and cathepsin L enzymes with <i>ex vivo</i> inhibition of SARS-CoV-2 entry and replication
Description

AbstractAs SARS-CoV-2 triggered a global health crisis, there is an urgent need to provide patients with safe, effective, accessible, and preferably oral therapeutics for COVID-19 that complement mRNA vaccines. Zinc compounds are widely known for their antiviral properties. Therefore, we have prepared a library of zinc complexes with pyrithione (1-hydroxy-2(1H)-pyridinethione) and its analogues, all of which showed promising in vitro inhibition of cathepsin L, an enzyme involved in SARS-CoV-2 entry, and PLPro, an enzyme involved in SARS-CoV-2 replication both in (sub)micromolar range. Zinc pyrithione 1a is a well-established, commercially available antimicrobial agent and was therefore selected for further evaluation of its SARS-CoV-2 entry and replication inhibition in an ex vivo system derived from primary human lung tissue. Our results suggest that zinc pyrithione complex 1a provides a multitarget approach to combat SARS-CoV-2 and should be considered for repurposing as a potential therapeutic against the insidious COVID-19 disease.Featured imageIn our study, we show that zinc pyrithione holds immense potential for the development of a possible out-patient treatment for SARS-CoV-2 due to its inhibition of viral entry and replication.

To read the original manuscript, click the link above.

Summary of Reviews: This preprint reports on the activity of commercially available Zinc pyrithione 1a drug for SARS-CoV-2 entry and replication inhibition using an ex vivo system.

Reviewer 1 (Momoh Yakabu) | πŸ“˜πŸ“˜πŸ“˜πŸ“˜πŸ“˜

Reviewer 2 (Tommaso Filippini) | πŸ“—πŸ“—πŸ“—πŸ“—β—»οΈ

RR:C19 Strength of Evidence Scale Key

πŸ“• ◻️◻️◻️◻️ = Misleading

πŸ“™πŸ“™ ◻️◻️◻️ = Not Informative

πŸ“’πŸ“’πŸ“’ ◻️◻️ = Potentially Informative

πŸ“—πŸ“—πŸ“—πŸ“—β—»οΈ = Reliable

πŸ“˜πŸ“˜πŸ“˜πŸ“˜πŸ“˜ = Strong

To read the reviews, click the links below.

Comments
2
Vape Factory:

https://china-vape-manufacturer.jimdosite.com/

https://vapecigreview.wordpress.com/

https://vapecigreview.wordpress.com/2022/11/29/the-vape-market-in-europe-and-the-u-s-and-europe/

https://vapecigreview.wordpress.com/2022/11/29/quit-smoking-with-electronic-cigarettes/

https://vapecigreview.wordpress.com/2022/11/29/differences-between-e-cigarettes-and-real-cigarettes/

https://vapecigreview.wordpress.com/2022/11/29/the-information-about-harm-from-vaping-is-a-lie/

https://vapecigreview.wordpress.com/2022/11/29/the-difference-between-shisha-and-vape/

https://sites.google.com/view/vapeecig/home

https://sites.google.com/view/vapeecig/what-is

https://vape-ecig.yolasite.com/minors/

https://ameblo.jp/vapecig/

https://ameblo.jp/vapecig/entry-12777111038.html

https://vapeall.godaddysites.com/

https://ecigatornew.wixsite.com/vape-all

https://ecigatornew.wixsite.com/vape-all/post/vape-kits-for-starters-that-are-recommended

https://ecigatornew.wixsite.com/vape-all/post/do-youngsters-in-the-uk-vape

https://ecigatornew.wixsite.com/vape-all/post/can-you-legally-vape-in-public-areas-across-the-uk

https://vapeall.company.site/

https://www.dibiz.com/ecigatornew

https://www.podcasts.com/vape-world/episode/what-flavors-are-available-in-vape-liquids

https://www.podcasts.com/vape-world/episode/what-is-a-vape

https://shows.acast.com/vape

https://shows.acast.com/vape/episodes/63aea263432cf00011f2292c

https://www.iheart.com/podcast/269-vape-106597071/

https://www.iheart.com/podcast/269-vape-106597071/episode/types-and-characteristics-of-cigarettes-106597072/

https://www.stitcher.com/show/vape/episode/types-and-characteristics-of-cigarettes-210376051

https://open.spotify.com/show/7ETRrXCYrJGOyIVwANFWr3

https://zeno.fm/podcast/vape/

https://zeno.fm/podcast/vape/episodes/types-and-characteristics-of-cigarettes/

https://ecigatornew.podbean.com/

https://www.podpage.com/vape

https://www.podpage.com/vape/types-and-characteristics-of-cigarettes/

https://www.pandora.com/podcast/description/vape/PC:1001050391

https://radiopublic.com/vape-WokMlx

https://radiopublic.com/vape-WokMlx/s1!03192

https://www.deezer.com/en/show/5580937

https://www.jiosaavn.com/shows/vape/1/5lgJ8Z6W9ZE_

https://www.listennotes.com/podcasts/vape-matthew-ma-VpDQs84fWk5/

https://pca.st/11mtna6b

https://player.fm/series/vape

https://castbox.fm/channel/Vape-id5279734

https://castbox.fm/episode/Types-and-Characteristics-of-Cigarettes-id5279734-id563203832

https://www.dropbox.com/scl/fi/gpyzyr9m4dragwrw3qd8h/.paper?dl=0&rlkey=llu2jxcsvpr89an5r7lm7mbsq

https://www.dropbox.com/scl/fi/b3zezf50xik87876pud1p/How-to-Charge-Your-Disposable-Vape.paper?dl=0&rlkey=rs9lwjv4zy4prixmdt4du81ip

https://airtable.com/shrjs9UWEbvRBC0Cw/tblsS8WnLCMHvhYoS

https://docs.google.com/spreadsheets/d/1BtkraXhEhY8OCP2aGjD6o-zvOjKA17zZiEj--qyPxQM/edit#gid=1745419682

https://docs.google.com/document/d/1PTaeusPUCeCQq6bFY64w_9qkt6DWuDjB7HT2U56EhJc/edit?usp=sharing

https://docs.google.com/document/d/1EnxJ-8p_gqHkAm7cHmusO2Q9LukHV1-LLIbSLERKAW4/edit

https://docs.google.com/presentation/d/1xL481Hon3BZfHnd63Ad84DqujIBj_u5Uob9NRoUipQo/edit?usp=sharing

https://colab.research.google.com/drive/1XzrOeND-o_x0-E-E06uElh8VQe6df4Bg?usp=sharing

https://www.deepsheet.net/U/url/7gama5yj

https://docs.qq.com/sheet/DU1F4Rm9iYm5DcWt0

https://docs.qq.com/doc/DU1JUb0hTd0VrU01q

https://kdocs.cn/l/ce9o0uUC4Dkv

https://kdocs.cn/l/cf0YSmv9WUo1

https://shimo.im/docs/1d3aVd9NEXiY7bqg/read

https://note.youdao.com/s/5MjlfFjG

https://datastudio.google.com/reporting/c4374f0f-a0ed-46db-8649-d5a848456236

https://groups.google.com/g/disposablevape/c/4Bu3h_cRbpM

https://workdrive.zohopublic.com/writer/open/hbuyb3ee69a8cae294889be237192718b4bcc

https://amazon.com/SekamCo-Apps-All-about-supplements/dp/B08BK7XSKR

https://amazon.es/SekamCo-Apps-All-about-supplements/dp/B08BK7XSKR

https://amazon.fr/SekamCo-Apps-All-about-supplements/dp/B08BK7XSKR

https://amazon.ca/SekamCo-Apps-All-about-supplements/dp/B08BK7XSKR

https://amazon.co.uk/SekamCo-Apps-All-about-supplements/dp/B08BK7XSKR

https://amazon.com.br/SekamCo-Apps-All-about-supplements/dp/B08BK7XSKR

https://amazon.in/SekamCo-Apps-All-about-supplements/dp/B08BK7XSKR

https://amazon.de/SekamCo-Apps-All-about-supplements/dp/B08BK7XSKR

https://amazon.it/SekamCo-Apps-All-about-supplements/dp/B08BK7XSKR

https://amazon.co.jp/SekamCo-Apps-All-about-supplements/dp/B08BK7XSKR

https://amazon.com.au/SekamCo-Apps-All-about-supplements/dp/B08BK7XSKR

?
Danielle Reyes:

Many studies and also many different results.

2 player games