Skip to main content
SearchLoginLogin or Signup

Review of "Increased Vaccine Sensitivity of an Emerging SARS-CoV-2 Variant"

Reviewer: S Alizon (Centre National de la Recherche Scientifique) | 📗📗📗📗◻️

Published onJul 11, 2023
Review of "Increased Vaccine Sensitivity of an Emerging SARS-CoV-2 Variant"
key-enterThis Pub is a Review of
Increased vaccine sensitivity of an emerging SARS-CoV-2 variant
Increased vaccine sensitivity of an emerging SARS-CoV-2 variant
Description

Host immune responses are a key source of selective pressure driving pathogen evolution. Emergence of many SARS-CoV-2 lineages has been associated with improvements in their ability to evade population immunity resulting from both vaccination and infection. Here we show diverging trends of escape from vaccine-derived and infection-derived immunity for the emerging XBB/XBB.1.5 Omicron lineage. Among 31,739 patients tested in ambulatory settings in Southern California from December, 2022 to February, 2023, adjusted odds of prior receipt of 2, 3, 4, and ≥5 COVID-19 vaccine doses were 10% (95% confidence interval: 1-18%), 11% (3-19%), 13% (3-21%), and 25% (15-34%) lower, respectively, among cases infected with XBB/XBB.1.5 than among cases infected with other co-circulating lineages. Similarly, prior vaccination was associated with greater protection against progression to hospitalization among cases with XBB/XBB.1.5 than among non-XBB/XBB.1.5 cases (70% [30-87%] and 48% [7-71%], respectively, for recipients of ≥4 doses). In contrast, cases infected with XBB/XBB.1.5 had 17% (11-24%) and 40% (19-65%) higher adjusted odds of having experienced 1 and ≥2 prior documented infections, respectively, including with pre-Omicron variants. As immunity acquired from SARS-CoV-2 infection becomes increasingly widespread, fitness costs associated with enhanced vaccine sensitivity in XBB/XBB.1.5 may be offset by increased ability to evade infection-derived host responses.

To read the original manuscript, click the link above.

Reviewer 1 (Samuel A…) | 📗📗📗📗◻️

RR:C19 Strength of Evidence Scale Key

📕 ◻️◻️◻️◻️ = Misleading

📙📙 ◻️◻️◻️ = Not Informative

📒📒📒 ◻️◻️ = Potentially Informative

📗📗📗📗◻️ = Reliable

📘📘📘📘📘 = Strong

To read the reviews, click the links below. 

Connections
1 of 1
Comments
1
?
elmthalysqoor elmthalysqoor:

شركة المثالي صقور لمكافحة الحشرات في الدمام هي شركة متخصصة ومعترف بها في مجال مكافحة الحشرات والآفات الضارة في المنطقة. تقدم هذه الشركة خدمات متميزة في التخلص من الحشرات المزعجة مثل الصراصير، والنمل، والبعوض، والصرصور، والآفات الأخرى.فريق العمل في شركة المثالي صقور مدرب بشكل جيد ويستخدم مبيدات آمنة وفعالة للقضاء على الحشرات بشكل فعال دون التأثير على البيئة أو صحة الإنسان. يهدفون إلى توفير بيئة نظيفة وصحية لعملائهم ومساعدتهم في التخلص من الحشرات بشكل دائم.بفضل خدمات شركة المثالي صقور لمكافحة الحشرات، يمكن لسكان الدمام الاستمتاع بحياة خالية من الحشرات والآفات الضارة في منازلهم ومكاتبهم. تعتبر هذه الشركة خيارًا ممتازًا لأولئك الذين يبحثون عن حلاً موثوقًا ومحترفًا لمكافحة الحشرات في المنطقة.

شركة رش الحشرات بالدمام