Reviews of "Is Higher Viral Load in SARS-CoV-2 Associated With Death?"

Maria Drogari-Apiranthitou; Chen Yeng; Michael Meisner

doi:doi:10.1162/2e3983f5.86328ae5

Reviews of "Is Higher Viral Load in SARS-CoV-2 Associated With Death?"

Reviewers: Maria Drogari-Apiranthitou (University of Athens) | 📒📒📒◻️◻️ • Chen Yeng (Universiti Malaya Fakulti Pergigian) | 📒📒📒◻️◻️ • Michael Meisner (Stadtisches Klinikum Dresden Standort Neustadt) | 📒📒📒◻️◻️

by Maria Drogari-Apiranthitou, Chen Yeng, and Michael Meisner

Published onSep 03, 2020

This Pub is a Review of

Is Higher Viral Load in SARS-CoV-2 Associated With Death?

by Klinger Soares Faico-Filho, Victor Cabelho Passarelli, and Nancy Bellei

Show Description
Published on Aug 06, 2020
www.medrxiv.org

Description

There is no proven prognostic marker or adequate number of studies in patients hospitalized for Coronavirus Disease-2019 (COVID-19). We conducted a retrospective cohort study of patients hospitalized with COVID-19 from March 14 to June 17, 2020, at Sao Paulo Hospital. SARS-CoV-2 viral load was assessed using the cycle threshold (Ct) values obtained from an RTPCR assay applied to the nasopharyngeal swab samples. Disease severity and patient outcomes were compared. Among the 875 patients, 50.1% (439/875) had mild, 30.4% (266/875) moderate, and 19.5% (170/875) severe disease. A Ct value of <25 (472/875) indicated a high viral load, which was independently associated with mortality (OR: 0,34; 95% CI: 0,217 to 0,533; p < 0.0001). Admission SARS-CoV-2 viral load is an important surrogate biomarker of infectivity and is independently associated with mortality among patients hospitalized with COVID-19.

To read the original manuscript, click the link above.

Summary of Reviews: This study is potentially informative but the results should be approached with caution. The claim that high viral load indicates higher mortality is not fully supported. Multiple confounding variables have not been taken into account.

Reviewer 1 (Maria Drogari-Apiranthitou) | 📒📒📒◻️◻️

Reviewer 2 (Chen Yeng) | 📒📒📒 ◻️◻️

Reviewer 3 (Michael Meisner) | 📒📒📒 ◻️◻️

RR:C19 Strength of Evidence Scale Key

📕 ◻️◻️◻️◻️ = Misleading

📙📙 ◻️◻️◻️ = Not Informative

📒📒📒 ◻️◻️ = Potentially Informative

📗📗📗📗◻️ = Reliable

📘📘📘📘📘 = Strong

To read the reviews, click the links below.

Connections

1 of 3

A Supplement to this Pub

Review 2: "Is Higher Viral Load in SARS-CoV-2 Associated With Death?"

by Chen Yeng

Show Description
Published on Sep 03, 2020
rrid.mitpress.mit.edu

Description

This study is potentially informative but the results should be approached with caution. The claim that high viral load indicates higher mortality is not fully supported. Multiple confounding variables have not been taken into account.

A Supplement to this Pub

Review 1: "Is Higher Viral Load in SARS-CoV-2 Associated With Death?"

by Maria Drogari-Apiranthitou

Show Description
Published on Sep 03, 2020
rrid.mitpress.mit.edu

Description

A Supplement to this Pub

Review 3: "Is Higher Viral Load in SARS-CoV-2 Associated With Death?"

by Michael Meisner

Show Description
Published on Sep 03, 2020
rrid.mitpress.mit.edu

Description

License

Creative Commons Attribution 4.0 International License (CC-BY 4.0)

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https://www.awkwardzombie.com/forum/viewtopic.php?f=2&t=296253&p=1547562#p1547562

https://www.crypto-city.com/forum/thread/9086/benefits-of-disposable-vapes/

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https://vapro.home.blog/2023/02/27/disposable-vape-vs-regular-vape-which-is-better/

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